Zhang Jing, Song Yong-Li, Tian Ke-Yong, Qiu Jian-Hua
Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710038, PR China.
Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710038, PR China.
Neurosci Lett. 2017 Feb 3;639:31-35. doi: 10.1016/j.neulet.2016.12.039. Epub 2016 Dec 19.
Noise-induced hearing loss (NIHL) is a serious health concern and prevention of hair cell death or therapeutic intervention at the early stage of NIHL is critical to preserve hearing. Minocycline is a semi-synthetic derivative of tetracycline and has been shown to have otoprotective effects in ototoxic drug-induced hearing impairment, however, whether minocycline can protect against NIHL has not been investigated. The present study demonstrated elevated ABR (auditory brainstem response) thresholds and outer hair cell loss following traumatic noise exposure, which was mitigated by intraperitoneal administration of minocycline (45mg/kg/d) for 5 consecutive days. In conclusion, the present study demonstrated that minocycline, a clinically approved drug with a good safety profile, can attenuate NIHL in rats and may potentially be used for treatment of hearing loss in clinic.
噪声性听力损失（NIHL）是一个严重的健康问题，在NIHL早期预防毛细胞死亡或进行治疗干预对于保护听力至关重要。米诺环素是四环素的半合成衍生物，已被证明在耳毒性药物引起的听力损害中具有耳保护作用，然而，米诺环素是否能预防NIHL尚未得到研究。本研究表明，创伤性噪声暴露后听觉脑干反应（ABR）阈值升高和外毛细胞损失，连续5天腹腔注射米诺环素（45mg/kg/d）可减轻这种情况。总之，本研究表明，米诺环素是一种临床批准的安全性良好的药物，可减轻大鼠的NIHL，并可能在临床上用于治疗听力损失。
