Berenger Byron, Chen Justin, Bernier Anne-Marie, Bernard Kathryn
Alberta Provincial Laboratory for Public Health, Edmonton, Alberta, Canada.
Division of Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada.
Genome Announc. 2016 Dec 22;4(6):e01442-16. doi: 10.1128/genomeA.01442-16.
Staphylococcus aureus strains without catalase activity are rare, challenging to identify with conventional biochemical methods, and, despite a supposed decreased pathogenicity, can still cause disease. The first whole-genome sequence of a catalase-negative S. aureus isolate causing severe recurrent invasive infection with two novel missense mutations in the katA gene is reported here.
无过氧化氢酶活性的金黄色葡萄球菌菌株很罕见,用传统生化方法鉴定具有挑战性,并且,尽管其致病性据推测有所降低,但仍可致病。本文报道了一株过氧化氢酶阴性金黄色葡萄球菌分离株的首个全基因组序列,该菌株导致严重复发性侵袭性感染,其katA基因存在两个新的错义突变。