Perez Katia M, Patel Niral J, Lord Jadienne H, Savin Kimberly L, Monzon Alexandra D, Whittemore Robin, Jaser Sarah S
Vanderbilt University Medical Center.
Yale School of Nursing.
J Pediatr Psychol. 2017 Jul 1;42(6):636-646. doi: 10.1093/jpepsy/jsw093.
Impairments in executive function (EF) skills have been observed in youth with type 1 diabetes (T1D), and these skills are critical for following the complex treatment regimen. This study examines parent reports of EF in relation to measures of adherence, glycemic control (A1c), and psychosocial outcomes (depression and quality of life) in adolescents with T1D. A total of 120 adolescents (aged 13-17 years, 52.5% female, 87.5% White) with T1D and their parents completed questionnaires. Glucometers were downloaded and A1c was obtained during clinical visits at the time of enrollment. The prevalence of clinically significant elevated scores on specific EF skills ranged from 11 to 18.6%. In multivariate analyses, parent-reported EF deficits were associated with poorer adherence and lower quality of life, explaining 13 and 12% of the variance, respectively. Adolescents with T1D exhibit specific EF deficits that may negatively impact their quality of life and their ability to engage in self-management activities.
1型糖尿病（T1D）青少年中已观察到执行功能（EF）技能受损，而这些技能对于遵循复杂的治疗方案至关重要。本研究调查了T1D青少年的父母报告的EF与依从性、血糖控制（糖化血红蛋白A1c）以及心理社会结果（抑郁和生活质量）指标之间的关系。共有120名患有T1D的青少年（年龄在13 - 17岁之间，52.5%为女性，87.5%为白人）及其父母完成了问卷调查。在入组时的临床访视期间下载血糖仪数据并获取糖化血红蛋白A1c。特定EF技能临床显著高分的患病率在11%至18.6%之间。在多变量分析中，父母报告的EF缺陷与较差的依从性和较低的生活质量相关，分别解释了13%和12%的方差。患有T1D的青少年表现出特定的EF缺陷，这可能会对他们的生活质量以及参与自我管理活动的能力产生负面影响。
