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CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D.

作者信息

Bruns H, Böttcher M, Qorraj M, Fabri M, Jitschin S, Dindorf J, Busch L, Jitschin R, Mackensen A, Mougiakakos D

机构信息

Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany.

Department of Dermatology, University of Cologne, Cologne, Germany.

出版信息

Leukemia. 2017 Apr;31(4):985-988. doi: 10.1038/leu.2016.378. Epub 2016 Dec 23.

DOI:10.1038/leu.2016.378
PMID:28008175
Abstract
摘要

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本文引用的文献

1
Exosomes and tumor-mediated immune suppression.外泌体与肿瘤介导的免疫抑制。
J Clin Invest. 2016 Apr 1;126(4):1216-23. doi: 10.1172/JCI81136. Epub 2016 Feb 29.
2
The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment.肿瘤微环境中髓源性抑制细胞的本质
Trends Immunol. 2016 Mar;37(3):208-220. doi: 10.1016/j.it.2016.01.004. Epub 2016 Feb 6.
3
mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors.mTOR掌控着同种异体移植或肿瘤小鼠模型中的单核骨髓来源抑制细胞。
维生素 D 补充剂可使早期慢性淋巴细胞白血病患者的首次治疗时间延长。
Blood Adv. 2024 Jul 23;8(14):3840-3846. doi: 10.1182/bloodadvances.2023011458.
4
Extracellular vesicles in hematological malignancies: EV-dence for reshaping the tumoral microenvironment.血液系统恶性肿瘤中的细胞外囊泡：重塑肿瘤微环境的细胞外囊泡证据
Front Immunol. 2023 Sep 26;14:1265969. doi: 10.3389/fimmu.2023.1265969. eCollection 2023.
5
Advances in the regulation of adipogenesis and lipid metabolism by exosomal ncRNAs and their role in related metabolic diseases.外泌体非编码RNA在脂肪生成和脂质代谢调控中的进展及其在相关代谢性疾病中的作用
Front Cell Dev Biol. 2023 Sep 18;11:1173904. doi: 10.3389/fcell.2023.1173904. eCollection 2023.
6
Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments.外泌体 miRNA 介导的细胞间通讯及在肿瘤微环境中的免疫调节作用。
J Biomed Sci. 2023 Aug 21;30(1):69. doi: 10.1186/s12929-023-00964-w.
7
Extracellular Vesicles in Chronic Lymphocytic Leukemia: Tumor Microenvironment Messengers as a Basis for New Targeted Therapies?慢性淋巴细胞白血病中的细胞外囊泡：作为新型靶向治疗基础的肿瘤微环境信使？
Cancers (Basel). 2023 Apr 14;15(8):2307. doi: 10.3390/cancers15082307.
8
Tumor-derived nanoseeds condition the soil for metastatic organotropism.肿瘤衍生的纳米种子为转移性器官亲嗜性创造条件。
Semin Cancer Biol. 2023 Aug;93:70-82. doi: 10.1016/j.semcancer.2023.05.003. Epub 2023 May 12.
9
Recent advances in the roles of exosomal microRNAs (exomiRs) in hematologic neoplasms: pathogenesis, diagnosis, and treatment.外泌体 microRNAs（exomiRs）在血液系统恶性肿瘤中的作用的最新进展：发病机制、诊断和治疗。
Cell Commun Signal. 2023 May 1;21(1):88. doi: 10.1186/s12964-023-01102-7.
10
Extracellular Vesicles (EVs) in Tumor Diagnosis and Therapy.细胞外囊泡（EVs）在肿瘤诊断和治疗中的应用。
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231171463. doi: 10.1177/15330338231171463.
Sci Rep. 2016 Feb 1;6:20250. doi: 10.1038/srep20250.
4
The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells.骨髓微环境通过外泌体介导的髓源性抑制细胞激活促进多发性骨髓瘤进展。
Oncotarget. 2015 Dec 22;6(41):43992-4004. doi: 10.18632/oncotarget.6083.
5
Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts.慢性淋巴细胞白血病细胞释放的外泌体可诱导基质细胞转变为癌症相关成纤维细胞。
Blood. 2015 Aug 27;126(9):1106-17. doi: 10.1182/blood-2014-12-618025. Epub 2015 Jun 22.
6
Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling.慢性淋巴细胞白血病（CLL）外泌体的特征揭示了独特的微小RNA特征以及通过BCR信号激活而增强的分泌。
Blood. 2015 May 21;125(21):3297-305. doi: 10.1182/blood-2014-12-618470. Epub 2015 Apr 1.
7
Vitamin D deficiency impairs rituximab-mediated cellular cytotoxicity and outcome of patients with diffuse large B-cell lymphoma treated with but not without rituximab.维生素 D 缺乏会损害利妥昔单抗介导的细胞毒性，并影响接受利妥昔单抗治疗的弥漫性大 B 细胞淋巴瘤患者的预后，但对未接受利妥昔单抗治疗的患者无影响。
J Clin Oncol. 2014 Oct 10;32(29):3242-8. doi: 10.1200/JCO.2013.53.4537. Epub 2014 Aug 18.
8
RAB11-mediated trafficking in host-pathogen interactions.Rab11 介导的宿主-病原体相互作用中的 trafficking。
Nat Rev Microbiol. 2014 Sep;12(9):624-34. doi: 10.1038/nrmicro3325.
9
MicroRNA-155 influences B-cell receptor signaling and associates with aggressive disease in chronic lymphocytic leukemia.微小RNA-155影响B细胞受体信号传导，并与慢性淋巴细胞白血病的侵袭性疾病相关。
Blood. 2014 Jul 24;124(4):546-54. doi: 10.1182/blood-2014-03-559690. Epub 2014 Jun 9.
10
CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs.CLL 细胞诱导 IDOhi CD14+HLA-DRlo 髓源抑制性细胞，抑制 T 细胞应答并促进 TRegs。
Blood. 2014 Jul 31;124(5):750-60. doi: 10.1182/blood-2013-12-546416. Epub 2014 May 21.