School of Medicine, Asian Liver Center, Stanford, CA, USA.
The Affiliated Cancer Hospital of Nanjing Medical University (Jiangsu Cancer Hospital) and Jiangsu Institute of Cancer Research, Nanjing, China.
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231171463. doi: 10.1177/15330338231171463.
In recent years, extracellular vesicles (EVs) have gained significant attention due to their tremendous potential for clinical applications. EVs play a crucial role in various aspects, including tumorigenesis, drug resistance, immune escape, and reconstruction of the tumor microenvironment. Despite the growing interest in EVs, many questions still need to be addressed before they can be practically applied in clinical settings. This paper aims to review EVs' isolation methods, structure research, the roles of EVs in tumorigenesis and their mechanisms in multiple types of tumors, their potential application in drug delivery, and the expectations for their future in clinical research.
近年来，细胞外囊泡（EVs）因其在临床应用方面的巨大潜力而受到广泛关注。EVs 在肿瘤发生、药物耐药、免疫逃逸和肿瘤微环境重建等方面发挥着关键作用。尽管人们对 EVs 的兴趣日益浓厚，但在它们实际应用于临床环境之前，仍有许多问题需要解决。本文旨在综述 EVs 的分离方法、结构研究、在肿瘤发生中的作用及其在多种类型肿瘤中的机制、在药物传递中的潜在应用，以及对其在临床研究中的未来的期望。
