Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
Nat Cell Biol. 2016 Dec 23;19(1):14-16. doi: 10.1038/ncb3457.
Cadherin adhesion complexes have recently emerged as sensors of tissue tension that regulate key developmental processes. Super-resolution microscopy experiments now unravel the spatial organization of the interface between cadherins and the actin cytoskeleton and reveal how vinculin, a central component in cadherin mechanotransduction, is regulated by mechanical and biochemical signals.
钙黏着蛋白黏附复合物最近被发现是组织张力的传感器，可调节关键的发育过程。超分辨率显微镜实验现在揭示了钙黏蛋白和肌动蛋白细胞骨架之间界面的空间组织，并揭示了黏着斑激酶（vinculin），作为钙黏蛋白机械转导的核心组成部分，如何受到机械和生化信号的调节。
