Raszeja Lukasz J, Siegmund Daniel, Cordes Anna L, Güldenhaupt Jörn, Gerwert Klaus, Hahn Stephan, Metzler-Nolte Nils
Faculty of Chemistry and Biochemistry, Inorganic Chemistry I - Bioinorganic Chemistry, Ruhr-University Bochum, Universitätsstr. 150, 44801 Bochum, Germany.
Chem Commun (Camb). 2017 Jan 16;53(5):905-908. doi: 10.1039/c6cc07553c. Epub 2016 Dec 23.
The synthesis and photophysical properties of a novel series of rhenium tricarbonyl complexes based on tridentate phenanthridinyl-containing ligands are described. Photophysical data reveal beneficial luminescence behaviour especially for compounds with an asymmetric ligand set. These advantageous properties are not limited to organic solvents, but indeed also improved in aqueous solutions. The suitability of our new rhenium complexes as potent imaging agents has been confirmed by fluorescence microscopy on living cancer cells, which also confirms superior long-time stability under fluorescence microscopy conditions. Colocalisation studies with commercial organelle stains reveal an accumulation of the complexes in the endoplasmic reticulum for all tested cell lines.
描述了基于含菲啶基三齿配体的一系列新型三羰基铼配合物的合成及其光物理性质。光物理数据表明，这些配合物具有良好的发光性能，尤其是对于具有不对称配体组的化合物。这些有利性质不仅限于有机溶剂，在水溶液中也有所改善。通过对活癌细胞进行荧光显微镜观察，证实了我们新合成的铼配合物作为有效成像剂的适用性，这也证实了其在荧光显微镜条件下具有出色的长期稳定性。与市售细胞器染色剂的共定位研究表明，所有测试细胞系中，这些配合物均在内质网中积累。
