人类白细胞抗原II类抗原在对乙肝表面抗原疫苗接种的体液无应答和延迟应答中的作用。

The contribution of HLA-Class II antigens in humoral non-response and delayed response to HBsAg vaccination.

作者信息

Vidan-Jeras Blanka, Brinovec Vlado, Jurca Bojan, Stezinar Snežna Levičnik, Jeras Matjaž, Bohinjec Mateja

机构信息

Blood Transfusion Centre of Slovenia, Slajmerjeva 6, 1000 Ljubljana, Slovenia, Slovenia.

Clinic for Infectious Disease, Medical Centre Ljubljana, 1525 Ljubljana, Slovenia, Slovenia.

出版信息

Pflugers Arch. 2000 Jan;440(Suppl 1):R188-R189. doi: 10.1007/s004240000059.

DOI:10.1007/s004240000059

PMID:28008535

Abstract

The variability in the immune response modulated by HLA alleles may be an important factor for the induction of the protective effect of HBsAg vaccines. We present here the analysis of HLA-DRB1, DQB1 and DQA1 alleles and their combinations in the group of 36 individuals with poor humoral immmune response to HBsAg vaccination. Comparison with the control group, consisted of 60 randomly choosen healthy subjects, revealed that the DRB11601, DQB10502, DQA10102 haplotype is overrepresented in the group of hyporesponders and may therefore be regarded as a factor influencing poor antibody responsiveness. We observed that after revaccination two of three individuals who failed to develop anti-HBs antibodies carry the same phenotype DRB10101,DRB10301;DQB10501, DQB10201;DQA10101,DQA1*0501, which supports the conjecture that immunogenicity of the HBsAg vaccine depends on specific combination of HLA DR and DQ molecules on antigen presenting cells.

摘要

由HLA等位基因调节的免疫反应变异性可能是诱导乙肝表面抗原（HBsAg）疫苗产生保护作用的一个重要因素。我们在此展示了对36名对HBsAg疫苗体液免疫反应不佳个体的HLA-DRB1、DQB1和DQA1等位基因及其组合的分析。与由60名随机选择的健康受试者组成的对照组相比，发现DRB11601、DQB10502、DQA10102单倍型在低反应者组中过度表达，因此可被视为影响抗体反应性差的一个因素。我们观察到，在再次接种疫苗后，三名未产生抗-HBs抗体的个体中有两名携带相同的表型DRB10101、DRB10301；DQB10501、DQB10201；DQA10101、DQA1*0501，这支持了HBsAg疫苗的免疫原性取决于抗原呈递细胞上HLA DR和DQ分子的特定组合这一推测。