微小RNA-335-5p和-3p协同作用抑制雌激素受体α表达并促进他莫昔芬耐药。
MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance.
作者信息
Martin Elizabeth C, Conger Adrienne K, Yan Thomas J, Hoang Van T, Miller David F B, Buechlein Aaron, Rusch Douglas B, Nephew Kenneth P, Collins-Burow Bridgette M, Burow Matthew E
机构信息
Department of Biological and Agricultural Engineering, Louisiana State University and LSU Agricultural Center, Baton Rouge, LA, USA.
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
FEBS Lett. 2017 Jan;591(2):382-392. doi: 10.1002/1873-3468.12538. Epub 2017 Jan 12.
Abstract
microRNAs (miRNAs) are small noncoding RNA molecules involved in the regulation of gene expression and play critical roles in human malignancies. Next-generation sequencing analysis of the MCF-7 breast cancer cell line overexpressing miR-335-5p and miR-335-3p demonstrated that the miRNA duplex repressed genes involved in the ERα signaling pathway, and enhanced resistance of MCF-7 cells to the growth inhibitory effects of tamoxifen. These data suggest that despite its conventional role in tumor suppression, the miR-335 transcript can also play an oncogenic role in promoting agonistic estrogen signaling in a cancerous setting.
摘要
微小RNA（miRNA）是参与基因表达调控的小型非编码RNA分子，在人类恶性肿瘤中发挥关键作用。对过表达miR-335-5p和miR-335-3p的MCF-7乳腺癌细胞系进行的下一代测序分析表明，该miRNA双链体抑制了参与雌激素受体α（ERα）信号通路的基因，并增强了MCF-7细胞对他莫昔芬生长抑制作用的抗性。这些数据表明，尽管miR-335转录本在肿瘤抑制中具有传统作用，但在癌性环境中，它也可能在促进雌激素激动信号传导方面发挥致癌作用。
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