Hornstein O P, Heyer G
Department of Dermatology, University of Erlangen-Nürnberg, FRG.
Acta Derm Venereol Suppl (Stockh). 1989;144:149-52. doi: 10.2340/00015555144149152.
Patients suffering from atopic eczema (AE) often exhibit general disturbances of vasovegetative skin functions. Thus, in 21 patients with AE we studied the response of the skin of one forearm to standardized 15-min exposure of the other forearm to a moderate cold bath (17-18 degrees C) and then, after a resting time, to a hot bath (40-41 degrees C). The results were compared with those in 23 age- and sex-matched healthy controls under the same experimental conditions. In most patients, the unilateral skin exposure to warmth left the temperature of the contralateral forearm nearly unchanged or even slightly decreased, whereas the exposure to cold induced either a slight rise in contralateral skin temperature or only a minute decrease. In contrast to the normal consensual temperature reaction of the non-exposed forearm to warmth exposure of the contralateral arm in most controls, the results in atopic patients indicate a "rigid" or even inverse ("paradoxical") response to the thermic stimuli applied. This abnormal pattern of thermoregulation may reflect an intrinsic disturbance of the peripheral and hypothalamic autonomous neural system involved in the pathogenetic conditions of AE.
患有特应性皮炎（AE）的患者常表现出血管营养性皮肤功能的全身性紊乱。因此，我们对21例AE患者进行了研究，让其一侧前臂皮肤接受标准化的15分钟暴露，即对另一侧前臂进行适度冷水浴（17 - 18摄氏度），然后在休息一段时间后，再进行热水浴（40 - 41摄氏度）。将结果与23名年龄和性别匹配的健康对照者在相同实验条件下的结果进行比较。在大多数患者中，单侧皮肤暴露于温暖环境时，对侧前臂的温度几乎不变甚至略有下降，而暴露于寒冷环境时，对侧皮肤温度要么略有上升，要么仅有微小下降。与大多数对照者中未暴露的前臂对侧臂温暖暴露的正常同感温度反应不同，特应性患者的结果表明其对所施加的热刺激有“僵化”甚至相反（“矛盾”）的反应。这种异常的体温调节模式可能反映了参与AE发病机制的外周和下丘脑自主神经系统的内在紊乱。
