Ruiz-Medrano Jorge, Pellegrini Marco, Cereda Matteo G, Cigada Mario, Staurenghi Giovanni
Eye Clinic, Department of Clinical Science "Luigi Sacco", University of Milano, Luigi Sacco Hospital, Milan - Italy.
Ophthalmology Unit, Clínico San Carlos University Hospital, Madrid - Spain.
Eur J Ophthalmol. 2017 Jun 26;27(4):476-480. doi: 10.5301/ejo.5000796. Epub 2016 Nov 19.
Central serous chorioretinopathy (CSC) is an idiopathic disorder characterized by serous detachments of the neurosensory retina and/or the retinal pigment epithelium affecting the macular area in the majority of cases. The objective of this study was to describe choroidal findings in patients with acute and chronic CSC based on enhanced depth imaging optical coherence tomography analysis.
This is a cross-sectional, noninterventional study performed at Luigi Sacco University Hospital of Milan. Inclusion criteria were the presence of diagnosed (acute or chronic) CSC and being 18 years or older. Patients were evaluated with Spectralis spectral-domain optical coherence tomography enhanced depth imaging by 2 operators. The main features analyzed were intrachoroidal hyperreflective spots and hyperreflective choroidal vessel walls, as actual measurements of wall thickness could not be performed.
Patients with chronic CSC had hyperreflective spots in 83.3% of the cases and hyperreflective choroidal vessel walls in 75%, whereas patients with acute course had the same alterations in 33% and 6.7% of cases, respectively.
These findings, if proven, may be indicative of chronic forms, thus guiding more accurate treatments and guiding clinicians through more accurate prognosis.
中心性浆液性脉络膜视网膜病变（CSC）是一种特发性疾病，其特征是神经感觉视网膜和/或视网膜色素上皮的浆液性脱离，大多数情况下累及黄斑区。本研究的目的是基于增强深度成像光学相干断层扫描分析描述急性和慢性CSC患者的脉络膜表现。
这是一项在米兰路易吉·萨科大学医院进行的横断面、非干预性研究。纳入标准为确诊（急性或慢性）CSC且年龄在18岁及以上。由2名操作人员使用Spectralis光谱域光学相干断层扫描增强深度成像对患者进行评估。分析的主要特征是脉络膜内高反射点和高反射脉络膜血管壁，因为无法进行血管壁厚度的实际测量。
慢性CSC患者中，83.3%的病例有高反射点，75%的病例有高反射脉络膜血管壁；而急性病程患者中，这两种改变分别见于33%和6.7%的病例。
这些发现若得到证实，可能提示慢性形式，从而指导更准确的治疗，并帮助临床医生做出更准确的预后判断。
