Polat Gultekin Burcu, Sahli Esra
Department of Ophthalmology, Ministry of Health Ankara City Hospital, Ankara 06800, Turkey.
Department of Ophthalmology, Ankara University Medical Faculty, Ankara, Turkey.
Ther Adv Ophthalmol. 2021 Mar 3;13:2515841421997195. doi: 10.1177/2515841421997195. eCollection 2021 Jan-Dec.
The aim of our study was to evaluate the macular pigment optical density in patients with acute and chronic central serous chorioretinopathy and to describe the association between central retinal thickness and choroidal thickness with the macular pigment optical density.
Eyes with acute central serous chorioretinopathy and chronic central serous chorioretinopathy (patients, who were diagnosed as having disease activity for 6 months) were included in this study. Macular pigment was measured using the heterochromatic flicker technique of the device for both eyes in patients with acute and chronic central serous chorioretinopathy and in control subjects.
Twenty-seven eyes with acute central serous chorioretinopathy, 23 eyes with chronic central serous chorioretinopathy, and 25 control eyes were enrolled. The mean macular pigment optical density in chronic central serous chorioretinopathy (0.480 ± 0.16 density unit (95% confidence interval: 0.390-0.570) was found to be significantly lower than in the control eyes (0.571 ± 0.128 density unit) (95% confidence interval: 0.480-0.670) ( = 0.007). In correlation analysis, no significant association was detected between the central retinal thickness, choroidal thickness, and macular pigment optical density values in central serous chorioretinopathy group ( = 0.31, = 0.71).
Macular pigment optical density levels were significantly lower in chronic central serous chorioretinopathy patients than in controls, possibly due to degeneration of the neurosensorial retina, as a result of the long-term persistence of subretinal fluid. There was not a significant correlation between choroidal thickness and macular pigment optical density levels in central serous chorioretinopathy group.
本研究旨在评估急性和慢性中心性浆液性脉络膜视网膜病变患者的黄斑色素光密度，并描述视网膜中心厚度和脉络膜厚度与黄斑色素光密度之间的关联。
本研究纳入了患有急性中心性浆液性脉络膜视网膜病变和慢性中心性浆液性脉络膜视网膜病变（诊断为疾病活动6个月的患者）的眼睛。使用该设备的异色闪烁技术对急性和慢性中心性浆液性脉络膜视网膜病变患者及对照受试者的双眼进行黄斑色素测量。
纳入了27只患有急性中心性浆液性脉络膜视网膜病变的眼睛、23只患有慢性中心性浆液性脉络膜视网膜病变的眼睛和25只对照眼睛。发现慢性中心性浆液性脉络膜视网膜病变患者的平均黄斑色素光密度（0.480±0.16密度单位（95%置信区间：0.390 - 0.570））显著低于对照眼睛（0.571±0.128密度单位）（95%置信区间：0.480 - 0.670）（P = 0.007）。在相关性分析中，中心性浆液性脉络膜视网膜病变组的视网膜中心厚度、脉络膜厚度和黄斑色素光密度值之间未检测到显著关联（P = 0.31，P = 0.71）。
慢性中心性浆液性脉络膜视网膜病变患者的黄斑色素光密度水平显著低于对照组，这可能是由于视网膜下液长期持续存在导致神经感觉视网膜变性所致。中心性浆液性脉络膜视网膜病变组中脉络膜厚度与黄斑色素光密度水平之间无显著相关性。
