基于多孔硅@乙酰化葡聚糖@癌细胞膜的多阶段纳米疫苗用于癌症免疫治疗。
Multistaged Nanovaccines Based on Porous Silicon@Acetalated Dextran@Cancer Cell Membrane for Cancer Immunotherapy.
机构信息
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014, Helsinki, Finland.
Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
出版信息
Adv Mater. 2017 Feb;29(7). doi: 10.1002/adma.201603239. Epub 2016 Dec 23.
Immunoadjuvant porous silicon (PSi)-based nanovaccines are prepared by nanoprecipitation in a glass capillary microfluidics device. Vesicles, derived from cancer cell membranes encapsulating thermally oxidized PSi nanoparticles or PSi-polymer nanosystems binding a model antigen, are biocompatible over a wide range of concentrations, and show immunostimulant properties in human cells, promoting the expression of co-stimulatory signals and the secretion of pro-inflammatory cytokines.
免疫佐剂多孔硅（PSi）基纳米疫苗是通过在玻璃毛细管微流控装置中进行纳米沉淀制备的。源自包封热氧化 PSi 纳米粒子或结合模型抗原的 PSi-聚合物纳米系统的囊泡在很宽的浓度范围内具有生物相容性，并在人细胞中表现出免疫刺激特性，促进共刺激信号的表达和促炎细胞因子的分泌。
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