Lindhardt Johansen Marie, Hagen Casper P, Mieritz Mikkel G, Wolthers Ole D, Heuck Carsten, Petersen Jørgen Holm, Juul Anders
Department of Growth and Reproduction, Rigshospitalet, DK-2100 Copenhagen, Denmark.
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health, University of Copenhagen, DK-2100 Copenhagen, Denmark.
J Clin Endocrinol Metab. 2017 Mar 1;102(3):1001-1008. doi: 10.1210/jc.2016-2871.
Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse, and the phenomenon of transient thelarche (TT), defined as the appearance, regression, and subsequent reappearance of breast buds, in healthy girls remains undescribed.
To describe TT in terms of pubertal progression, growth, genotypes, and reproductive hormones and to apply new puberty nomograms for breast stages, pubic hair, and menarche.
A prospective, longitudinal population-based study.
Ninety-eight healthy Danish schoolchildren (Caucasian girls) followed longitudinally as part of the COPENHAGEN Puberty Study were included in the evaluation of TT. A total of 1466 girls from 2 cross-sectional studies were included in the creation of the puberty nomograms.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Pubertal progression, specifically thelarche, reproductive hormones, genotype, and growth.
Twelve of 98 (12%) girls experienced TT. A larger proportion of girls with TT entered puberty by the pubarche pathway (50%) compared with girls with normal progression (15.4%), P = 0.014. Girls with TT progressed through puberty normally when evaluated using puberty nomograms. Reproductive hormones and growth velocity were lower at the first (transient) thelarche than the second (permanent) thelarche.
TT is a frequent phenomenon that appears to be a peripheral occurrence independent of central puberty. It does not appear to affect subsequent pubertal progression as evaluated by our new puberty nomograms.
纵向研究对女孩青春期发育的详细评估较少，健康女孩中短暂性乳房发育（TT）现象（定义为乳房芽出现、消退及随后再次出现）仍未得到描述。
从青春期发育、生长、基因型和生殖激素方面描述TT，并应用新的青春期乳房分期、阴毛和初潮发育图谱。
一项基于人群的前瞻性纵向研究。
作为哥本哈根青春期研究一部分而进行纵向随访的98名健康丹麦学童（白种女孩）被纳入TT评估。两项横断面研究中的1466名女孩被纳入青春期发育图谱的创建。
无。
青春期发育，特别是乳房发育、生殖激素、基因型和生长。
98名女孩中有12名（12%）经历了TT。与正常发育的女孩（15.4%）相比，TT女孩中通过阴毛发育途径进入青春期的比例更高（50%），P = 0.014。使用青春期发育图谱评估时，TT女孩青春期发育正常。第一次（短暂性）乳房发育时的生殖激素和生长速度低于第二次（永久性）乳房发育时。
TT是一种常见现象，似乎是一种独立于中枢性青春期的外周现象。根据我们新的青春期发育图谱评估，它似乎不影响随后的青春期发育。
