Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Department of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
BMJ Open. 2022 Feb 3;12(2):e057088. doi: 10.1136/bmjopen-2021-057088.
To compare the usefulness of the classical definition of delayed puberty (DP) in boys with puberty nomograms and to describe the management of DP in boys in a hospital-based setting.
Observational retrospective multicentre study with a short-term follow-up.
Boys diagnosed with DP during 2013-2015 at paediatric departments in four counties in central Sweden. The medical records of 165 boys were reviewed.
Number of boys with DP after re-evaluation of the diagnosis according to the classical definition in comparison with puberty nomograms. Description of investigations performed and treatment provided to boys with DP.
In total, 45 and 58 boys were found to have DP according to the classical definition and the nomograms, respectively. Biochemical and/or radiological testing was performed in 91% of the 58 boys, but an underlying disease was only found in 9% of them. Approximately 79% of the boys received testosterone treatment, either as injections of testosterone enanthate or as testosterone undecanoate.
Puberty nomograms may be helpful instruments when diagnosing pubertal disorders in boys as they are not limited to an age close to 14 years and also identify boys with pubertal arrest. The majority of boys with DP undergo biochemical or radiological examinations, but underlying diseases are unusual emphasising the need for structural clinical practice guidelines for this patient group.
比较经典的青春期延迟（DP）定义与青春期图谱在男孩中的应用价值，并描述在医院环境中男孩 DP 的管理方法。
一项具有短期随访的观察性回顾性多中心研究。
2013 年至 2015 年期间，在瑞典中部四个县的儿科部门诊断为 DP 的男孩。对 165 名男孩的病历进行了回顾。
根据经典定义与青春期图谱重新评估诊断后 DP 男孩的数量。描述对 DP 男孩进行的检查和治疗。
根据经典定义和图谱，分别有 45 名和 58 名男孩被诊断为 DP。对 58 名男孩中的 91%进行了生化和/或影像学检查，但仅在其中 9%的男孩中发现了潜在疾病。大约 79%的男孩接受了睾酮治疗，要么是注射庚酸睾酮，要么是十一酸睾酮。
青春期图谱可能是诊断男孩青春期障碍的有用工具，因为它们不仅限于接近 14 岁的年龄，还可以识别青春期停滞的男孩。大多数 DP 男孩接受了生化或影像学检查，但潜在疾病并不常见，这强调了为该患者群体制定结构性临床实践指南的必要性。
