在一例暴发性紫癜致死病例中死后长时间检测到肺炎链球菌

Streptococcus Pneumoniae Detection Long Time After Death in a Fatal Case of Waterhouse-Friderichsen Syndrome.

作者信息

Verzeletti Andrea, Bonfanti Carlo, Leide Anna, Azzalini Elena, De Francesco Maria Antonia, Piccinelli Giorgio, De Ferrari Francesco

机构信息

From the *Forensic Medicine Unit, Section of Public Health and Human Sciences, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, and †Microbiology Section, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

出版信息

Am J Forensic Med Pathol. 2017 Mar;38(1):18-20. doi: 10.1097/PAF.0000000000000284.

DOI:10.1097/PAF.0000000000000284

PMID:28009598

Abstract

We report a fatal case of Waterhouse-Friderichsen syndrome in a 64-year-old man. The diagnosis, suspected during the autopsy (performed 63 hours after death), was confirmed through the successful detection of Streptococcus pneumoniae DNA and antigens in samples (blood and liver) collected during the autopsy. These results conformed with blood cultures performed antemortem, which became available only the day after the autopsy. The case underlines the need to collect biological material (liver and blood samples) during autopsy for microbiological investigations, although the collection is performed a long time after the death, suggesting that a liver sample works for DNA and liver and blood work for Streptococcus pneumoniae antigen detection.

摘要

我们报告了一例64岁男性患华-弗综合征致死的病例。尸检（在死亡63小时后进行）时怀疑的诊断，通过在尸检期间采集的样本（血液和肝脏）中成功检测到肺炎链球菌DNA和抗原而得到证实。这些结果与生前进行的血培养结果相符，而血培养结果在尸检后一天才获得。该病例强调了在尸检时采集生物材料（肝脏和血液样本）进行微生物学调查的必要性，尽管采集是在死亡很长时间后进行的，这表明肝脏样本可用于DNA检测，肝脏和血液样本可用于肺炎链球菌抗原检测。