Tsokos Michael
Institute of Legal Medicine, Department of Forensic Pathology, Hamburg, Germany.
Am J Forensic Med Pathol. 2003 Mar;24(1):41-4. doi: 10.1097/01.PAF.0000051704.91568.A6.
A fatal case of Waterhouse-Friderichsen syndrome resulting from infection in a previously healthy 74-year-old woman is reported. The patient died suddenly within 14 hours after presentation. The diagnosis of Waterhouse-Friderichsen syndrome as the cause of death was established post mortem based on autopsy findings, microscopic examination, measurement of serum procalcitonin concentration (113 ng/ml), and outcome of postmortem bacteriologic cultures that grew in heart and spleen blood samples. Since the introduction of as a new group in the family in 1983, more recent case studies have established its clinical significance and pathogenic potential to cause severe, life-threatening bacteremia and sepsis. is a rare pathogen that should be added to the list of unusual bacteria causing Waterhouse-Friderichsen syndrome.
报告了一例先前健康的74岁女性因感染导致的华-佛综合征致死病例。患者在就诊后14小时内突然死亡。死后根据尸检结果、显微镜检查、血清降钙素原浓度测定(113 ng/ml)以及心脏和脾脏血样中培养出的死后细菌学培养结果,确定华-佛综合征为死因。自1983年作为该菌属中的一个新组被引入以来,最近的病例研究已证实其临床意义以及导致严重、危及生命的菌血症和败血症的致病潜力。是一种罕见病原体,应添加到导致华-佛综合征的不常见细菌名单中。