Sreedharanunni Sreejesh, Ahluwalia Jasmina, Kumar Narender, Bose Sunil K, Dhawan Rishi, Malhotra Pankaj
aDepartment of Hematology bDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Blood Coagul Fibrinolysis. 2017 Jul;28(5):416-418. doi: 10.1097/MBC.0000000000000615.
: We report a 14-year-old girl who presented with subdural hematoma and a deranged coagulation profile suggestive of an inhibitor. Investigations revealed prothrombin deficiency along with positivity for antiphospholipid antibodies, which improved with steroid therapy. Bleeding diathesis in children and adolescents commonly results from thrombocytopenia, platelet function disorders, or coagulation factor deficiency; whereas bleeding because of coagulation factor inhibitors are extremely rare in this age group. This case also highlights the uncommon presentation of antiphospholipid antibody syndrome, as they often present with thrombosis or pregnancy complications rather than bleeding.
我们报告了一名14岁女孩，她出现了硬膜下血肿和提示存在抑制剂的凝血功能紊乱。检查发现凝血酶原缺乏以及抗磷脂抗体呈阳性，经类固醇治疗后有所改善。儿童和青少年的出血倾向通常由血小板减少、血小板功能障碍或凝血因子缺乏引起；而在这个年龄组中，因凝血因子抑制剂导致的出血极为罕见。该病例还凸显了抗磷脂抗体综合征不常见的表现形式，因为它们通常表现为血栓形成或妊娠并发症而非出血。
