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低凝血酶原血症及与狼疮抗凝物相关的严重出血。

Hypoprothrombinemia and severe hemorrhage associated with a lupus anticoagulant.

作者信息

Bernini J C, Buchanan G R, Ashcraft J

机构信息

University of Texas Southwestern Medical Center at Dallas.

出版信息

J Pediatr. 1993 Dec;123(6):937-9. doi: 10.1016/s0022-3476(05)80390-7.

DOI:10.1016/s0022-3476(05)80390-7
PMID:8229526
Abstract

We recently encountered a previously healthy 3-year-old girl who had severe bleeding resulting from a severe deficiency of prothrombin. A lupus anticoagulant was identified by several different methods. The patient was successfully treated with glucocorticoids. This rare complication of a lupus anticoagulant should be considered in the differential diagnosis of a previously well child who suddenly has hemorrhage.

摘要

我们最近遇到一名此前健康的3岁女童,她因凝血酶原严重缺乏而出现严重出血。通过几种不同方法检测出狼疮抗凝物。该患者接受糖皮质激素治疗后康复。对于突然出现出血症状的此前健康儿童,在鉴别诊断时应考虑狼疮抗凝物这一罕见并发症。

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引用本文的文献

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Prevalence and Resolution of Lupus Anticoagulant in Children.儿童狼疮抗凝物的患病率及转归
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Lupus anticoagulant hypoprothrombinemia syndrome in Bence-Jones protein κ-type multiple myeloma patient with phosphatidylserine-dependent antiprothrombin antibody.
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