Ording H
Department of Anaesthesia, Herlev University Hospital, Denmark.
Acta Anaesthesiol Scand. 1989 Jul;33(5):405-8. doi: 10.1111/j.1399-6576.1989.tb02933.x.
In vitro contracture tests for susceptibility to malignant hyperthermia (MH) were performed with halothane and caffeine in 27 patients according to the protocol of the European MH Group. Additional halothane and caffeine tests were performed in the presence of propranolol 80 micrograms/l. Contractures after exposure to halothane were seen only in MH-susceptible (MHS) patients (n = 12), and were not affected by propranolol. In contrast, propranolol shifted the caffeine dose-response curve to the right and significantly increased the caffeine threshold in the MHS group. Propranolol did not influence the caffeine results in the normal response group group (n = 12). It is concluded that beta-blockers should be discontinued before investigation for MH susceptibility.
根据欧洲恶性高热（MH）研究小组的方案，对27例患者进行了氟烷和咖啡因诱发的体外挛缩试验以检测其对MH的易感性。在存在80微克/升普萘洛尔的情况下进行了额外的氟烷和咖啡因试验。仅在MH易感（MHS）患者（n = 12）中观察到氟烷暴露后的挛缩，且不受普萘洛尔影响。相比之下，普萘洛尔使MHS组的咖啡因剂量反应曲线右移，并显著提高了咖啡因阈值。普萘洛尔对正常反应组（n = 12）的咖啡因试验结果无影响。得出的结论是，在进行MH易感性调查之前应停用β受体阻滞剂。
