沙丁胺醇对恶性高热时肌肉体外对咖啡因和氟烷反应的影响。

Influence of salbutamol on the in vitro muscle response to caffeine and halothane in malignant hyperthermia.

作者信息

Bendixen D, Ording H

机构信息

Department of Anaesthesia, Rigshospitalet, Copenhagen, Denmark.

出版信息

Acta Anaesthesiol Scand. 1990 Nov;34(8):658-61. doi: 10.1111/j.1399-6576.1990.tb03167.x.

DOI:10.1111/j.1399-6576.1990.tb03167.x

PMID:2275327

Abstract

In vitro contracture tests for susceptibility to malignant hyperthermia (MH) were performed with halothane and caffeine in 34 patients, according to the protocol of the European MH Group. Additional halothane and caffeine tests were performed in the presence of salbutamol 50 micrograms/l. Contractures after exposure to halothane were seen only in MH-susceptible (MHS) patients (n = 16), and were not changed by salbutamol. Salbutamol did not influence the caffeine dose-response curves in any of the groups (n = 14 in the MH-non-susceptible (MHN) group). The caffeine threshold concentration was significantly increased by salbutamol in the MHS group.

摘要

根据欧洲恶性高热（MH）研究小组的方案，对34例患者使用氟烷和咖啡因进行了体外恶性高热易感性挛缩试验。在50微克/升沙丁胺醇存在的情况下，额外进行了氟烷和咖啡因试验。仅在恶性高热易感（MHS）患者（n = 16）中观察到氟烷暴露后的挛缩，且不受沙丁胺醇影响。沙丁胺醇对任何组（MH非易感（MHN）组n = 14）的咖啡因剂量反应曲线均无影响。沙丁胺醇使MHS组的咖啡因阈值浓度显著升高。