Feilberg V L, Rosenborg D, Broen Christensen C, Mogensen J V
Department of Anaesthesiology, Herlev Hospital, Denmark.
Acta Anaesthesiol Scand. 1989 Jul;33(5):426-8. doi: 10.1111/j.1399-6576.1989.tb02938.x.
Five lactating women who underwent surgery and were treated with morphine epidurally or IV/IM in the postoperative phase were included in the study. The morphine concentrations in plasma and breast milk were determined 0, 15, 30, 45, 60, 90, 120, 240, 360 and 480 min after drug administration by means of a specific radioimmunoassay for morphine. The milk-to-plasma ratio was 2.45 +/- 0.8 (mean +/- s.d.). The amount of morphine transferred by nursing is, even at the peak concentration of 500 ng/ml milk, small and will hardly cause respiratory depression or drowsiness in the child.
五名接受手术并在术后阶段接受硬膜外或静脉/肌肉注射吗啡治疗的哺乳期妇女被纳入该研究。通过一种针对吗啡的特异性放射免疫分析法，在给药后0、15、30、45、60、90、120、240、360和480分钟测定血浆和母乳中的吗啡浓度。母乳与血浆的比率为2.45±0.8（平均值±标准差）。即使在母乳中吗啡浓度达到峰值500纳克/毫升时，通过哺乳转移的吗啡量也很少，几乎不会导致婴儿呼吸抑制或嗜睡。
