Liu Zeming, Zeng Wen, Chen Tianwen, Guo Yawen, Zhang Chao, Liu Chunping, Huang Tao
Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Ophthalmology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China.
Oncotarget. 2017 Jan 24;8(4):6222-6232. doi: 10.18632/oncotarget.14055.
Papillary thyroid cancer (PTC) accounts for 80-90% of all thyroid malignancies. The tall cell variant (TCV) is a rare aggressive histotype of PTC. We performed a meta-analysis to compare the clinicopathological characteristics and prognostic factors of TCV with those of classical papillary thyroid carcinoma (cPTC). A literature search was performed using the PubMed and EMBASE databases using Medical Subject Headings and keywords. Twenty studies that included 1871 patients with TCV and 75323 patients with cPTC were included in our meta-analysis. Odds ratios and confidence intervals were calculated for each study. Patients with TCV were associated with multifocality, higher TNM stage, extrathyroidal extension, vascular invasion, lymph node metastasis, distant metastasis, BRAF mutation, disease-specific survival, and overall survival. We found that TCV cases were associated with more aggressive clinicopathological characteristics and poorer prognoses than cPTC cases were. Our results suggest that TCV is a high-risk PTC that warrants aggressive treatment and follow-up strategies.
甲状腺乳头状癌（PTC）占所有甲状腺恶性肿瘤的80 - 90%。高细胞变体（TCV）是PTC一种罕见的侵袭性组织学类型。我们进行了一项荟萃分析，以比较TCV与经典甲状腺乳头状癌（cPTC）的临床病理特征和预后因素。使用医学主题词和关键词在PubMed和EMBASE数据库中进行文献检索。我们的荟萃分析纳入了20项研究，其中包括1871例TCV患者和75323例cPTC患者。计算每项研究的比值比和置信区间。TCV患者与多灶性、更高的TNM分期、甲状腺外侵犯、血管侵犯、淋巴结转移、远处转移、BRAF突变、疾病特异性生存和总生存相关。我们发现，与cPTC病例相比，TCV病例具有更具侵袭性的临床病理特征和更差的预后。我们的结果表明，TCV是一种高危PTC，需要积极的治疗和随访策略。
