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代谢酶：癌症干细胞样细胞功能的关键调节因子。

Metabolic enzymes: key modulators of functionality in cancer stem-like cells.

作者信息

Dong Bo-Wen, Qin Guang-Ming, Luo Yan, Mao Jian-Shan

机构信息

Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Department of Clinical Laboratory Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Oncotarget. 2017 Feb 21;8(8):14251-14267. doi: 10.18632/oncotarget.14041.

DOI:10.18632/oncotarget.14041
PMID:28009990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5355174/
Abstract

Cancer Stem-like Cells (CSCs) are a subpopulation of cancer cells with self-renewal capacity and are important for the initiation, progression and recurrence of cancer diseases. The metabolic profile of CSCs is consistent with their stem-like properties. Studies have indicated that enzymes, the main regulators of cellular metabolism, dictate functionalities of CSCs in both catalysis-dependent and catalysis-independent manners. This paper reviews diverse studies of metabolic enzymes, and describes the effects of these enzymes on metabolic adaptation, gene transcription and signal transduction, in CSCs.

摘要

癌症干细胞（CSCs）是具有自我更新能力的癌细胞亚群，对癌症疾病的起始、进展和复发至关重要。癌症干细胞的代谢特征与其干细胞样特性一致。研究表明，作为细胞代谢主要调节因子的酶，以催化依赖和非催化依赖的方式决定癌症干细胞的功能。本文综述了对代谢酶的各种研究，并描述了这些酶对癌症干细胞中代谢适应、基因转录和信号转导的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/4872a16a0e9c/oncotarget-08-14251-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/08f314ca2e2c/oncotarget-08-14251-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/a4f0547d7aa4/oncotarget-08-14251-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/23aecf4d8184/oncotarget-08-14251-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/aece77c298e8/oncotarget-08-14251-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/542e485630df/oncotarget-08-14251-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/4872a16a0e9c/oncotarget-08-14251-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/08f314ca2e2c/oncotarget-08-14251-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/a4f0547d7aa4/oncotarget-08-14251-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/23aecf4d8184/oncotarget-08-14251-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/aece77c298e8/oncotarget-08-14251-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/542e485630df/oncotarget-08-14251-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fb0/5355174/4872a16a0e9c/oncotarget-08-14251-g006.jpg

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