Frost-Larsen K, Lund-Anderson C, Starup K
Department of Ophthalmology, Gentofte Hospital, University of COpenhagen, Denmark.
Acta Ophthalmol (Copenh). 1989 Aug;67(4):401-4. doi: 10.1111/j.1755-3768.1989.tb01623.x.
The relationship between the macular recovery recorded by nyctometry and the retinal findings was examined in 60 initially pre-pubescent children with insulin-dependent diabetes mellitus during a 6-year period with special reference to the clinical applicability of nyctometry in selecting children and adolescents at risk of developing proliferative diabetic retinopathy. At the end of the study period the mean age of the patients was 21.9 years (range 18-23 years) and the mean diabetes duration 13.2 years (range 8.1-21.2 years). At the initial recording of macular recovery, only 7% of the children showed retinopathy, and this only in the form of a few microaneurysms or dot haemorrhages. During the study period, however, nearly all (93%) developed retinopathy, and in 9 (14%) the disease progressed into proliferative retinopathy. The initially recorded macular recovery time (MRI) of those children developing proliferative retinopathy was significantly lower (616 +/- 95; X +/- SEM) compared to the initial MRT performances (900 +/- 47) of the rest of the children. However, due to a high coefficient of variation in the material; predictive sensitivity showed low (56%) at a specificity level of 90%, suggesting that nyctometry is less suitable for selecting risk patients in children than in adults.
在6年期间，对60名最初处于青春期前的胰岛素依赖型糖尿病患儿进行了研究，以检查视网膜电流图记录的黄斑恢复情况与视网膜检查结果之间的关系，特别关注视网膜电流图在选择有发生增殖性糖尿病视网膜病变风险的儿童和青少年中的临床适用性。在研究期结束时，患者的平均年龄为21.9岁（范围18 - 23岁），平均糖尿病病程为13.2年（范围8.1 - 21.2年）。在最初记录黄斑恢复情况时，只有7%的儿童出现视网膜病变，且仅表现为少数微动脉瘤或点状出血。然而，在研究期间，几乎所有患儿（93%）都发展为视网膜病变，其中9名（14%）患儿病情进展为增殖性视网膜病变。与其余儿童最初的黄斑恢复时间（MRT）表现（900±47）相比，那些发展为增殖性视网膜病变的儿童最初记录的黄斑恢复时间（MRI）显著更低（616±95；X±SEM）。然而，由于该材料的变异系数较高，在特异性水平为90%时，预测敏感性较低（56%），这表明视网膜电流图在选择儿童风险患者方面不如在成人中适用。
