Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
Asian J Surg. 2018 Mar;41(2):115-123. doi: 10.1016/j.asjsur.2016.11.009. Epub 2016 Dec 20.
Pancreatic ductal adenocarcinoma is one of the most malignant types of cancer. This study evaluated the 3-year and 5-year surgical outcomes associated with the cancer and determined whether statistically identified factors can be used to predict survival.
This retrospective review was conducted from 1995 to 2010. Patients who had resectable pancreatic ductal adenocarcinoma and received surgical treatment were included. Cases of hospital mortality were excluded. The relationships between several clinicopathological factors and the survival rate were analyzed.
A total of 223 patients were included in this study. The 3-year and 5-year survival rates were 21.4% and 10.1%, respectively, and the median survival was 16.1 months. Tumor size, N status, and resection margins were independent predictive factors for 3-year survival. Tumor size independently predicted 5-year survival.
Tumor size is the most important independent prognostic factor for 3-year and 5-year survival. Lymph node status and the resection margins also independently affected the 3-year survival. These patient outcomes might be improved by early diagnosis and radical resection. Future studies should focus on the tumor biology of this aggressive cancer.
胰腺导管腺癌是最恶性的癌症类型之一。本研究评估了与癌症相关的 3 年和 5 年手术结果，并确定是否可以使用统计学确定的因素来预测生存率。
这是一项回顾性研究，时间为 1995 年至 2010 年。纳入接受手术治疗的可切除胰腺导管腺癌患者。排除住院死亡病例。分析了几种临床病理因素与生存率之间的关系。
本研究共纳入 223 例患者。3 年和 5 年生存率分别为 21.4%和 10.1%，中位生存期为 16.1 个月。肿瘤大小、N 状态和切缘是 3 年生存率的独立预测因素。肿瘤大小独立预测 5 年生存率。
肿瘤大小是 3 年和 5 年生存率的最重要独立预后因素。淋巴结状态和切缘也独立影响 3 年生存率。通过早期诊断和根治性切除，这些患者的结局可能会得到改善。未来的研究应集中在这种侵袭性癌症的肿瘤生物学上。
