立体定向体部放疗用于治疗结直肠癌肺寡转移患者。
Stereotactic Body Radiotherapy in Patients with Lung Oligometastases from Colorectal Cancer.
作者信息
Pasqualetti Francesco, Montrone Sabrina, Vivaldi Caterina, Zani Margherita, Fedele David, Fornaro Lorenzo, Pasqualetti Giuseppe, Salvatore Lisa, Manfredi Bruno, Laliscia Concetta, Coraggio Gabriele, Gonnelli Alessandra, Loupakis Fotios, Masi Gianluca, Sainato Aldo, Monzani Fabio, Falcone Alfredo, Paiar Fabiola
机构信息
Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy
Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy.
出版信息
Anticancer Res. 2017 Jan;37(1):315-319. doi: 10.21873/anticanres.11323.
AIM
To assess the role of stereotactic body radiotherapy (SBRT) in pulmonary metastases from colorectal cancer (CRC).
PATIENTS AND METHODS
Thirty-three consecutive patients with pulmonary metastases from CRC who received SBRT were included in the analysis. The primary endpoints were local and systemic progression-free survival, a secondary endpoint was the safety profile of SBRT.
RESULTS
A total of 56 lesions were treated with SBRT. A single nodule was treated in 15 patients, two in 13 and three in five. The radiotherapy dose and the adopted fractionations were 24-27 Gy as a single fraction for 40 lesions and 27-42 Gy in three fractions (2-3 times a week) for the other 16 lesions. After a median follow-up of 22.8 months (range=1.3-45.7 months), the median progression-free survival of the irradiated sites was 13.4 months.
CONCLUSION
SBRT can be considered as local therapy in patients with lung metastases from CRC.
目的
评估立体定向体部放疗（SBRT）在结直肠癌（CRC）肺转移中的作用。
患者与方法
分析33例接受SBRT治疗的CRC肺转移患者。主要终点为局部和全身无进展生存期，次要终点为SBRT的安全性。
结果
共56个病灶接受SBRT治疗。15例患者治疗单个结节，13例治疗2个，5例治疗3个。放疗剂量及分割方式为：40个病灶单次剂量24 - 27 Gy，另外16个病灶分3次（每周2 - 3次）给予27 - 42 Gy。中位随访22.8个月（范围1.3 - 45.7个月），照射部位的中位无进展生存期为13.4个月。
结论
SBRT可被视为CRC肺转移患者的局部治疗方法。
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