Ohguri Takayuki, Kakinouchi Sho, Imada Hajime, Matsuyama Atsuji, Yahara Katsuya, Nakahara Sota, Hohchi Nobusuke, Suzuki Hideaki, Korogi Yukunori
Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Department of Cancer Therapy Center, Tobata Kyoritsu Hospital, Kitakyushu, Japan.
Nagoya J Med Sci. 2020 Feb;82(1):135-141. doi: 10.18999/nagjms.82.1.135.
Systemic chemotherapy is a standard treatment for Stage IVc nasopharyngeal carcinoma (NPC). Stage IVc NPC patients with oligometastases have a better prognosis, and local therapy has an important role in further development of the disease. However, the efficacy of local therapy to the metastases in patients with multiple-site and/or multiple-organ metastases is limited due to the aggressive behavior of the tumor. We report a NPC case in a pediatric patient with repeated oligometastases involving the bone, liver and distant lymph nodes who achieved 10-year disease free status after initial chemotherapy and radiotherapy to all the metastases. This very rare case demonstrated that radiotherapy to oligometastatic lesions have a potential to cure repeated oligometastases which involved multiple-organ metastases in a pediatric NPC with stage IVc.
全身化疗是IVc期鼻咽癌（NPC）的标准治疗方法。寡转移的IVc期NPC患者预后较好，局部治疗在疾病的进一步发展中具有重要作用。然而，由于肿瘤的侵袭性，局部治疗对多部位和/或多器官转移患者转移灶的疗效有限。我们报告了1例儿科NPC患者，其反复出现骨、肝和远处淋巴结寡转移，在对所有转移灶进行初始化疗和放疗后获得了10年无病生存状态。这个非常罕见的病例表明，对寡转移病灶进行放疗有可能治愈IVc期儿科NPC中涉及多器官转移的反复寡转移。
