Mahyar Abolfazl, Ayazi Parviz, Ahmadi Negin Khoshbakht, Pour Nikoo Sara Talebi, Hamzehloo Samaneh, Taremiha Alireza, Yazdi Zohreh, Esmaeily Shiva
Department of Paediatrics, Qazvin Children Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Medical College of Qazvin University of Medical Sciences, Qazvin, Iran.
Infez Med. 2016 Dec 1;24(4):331-336.
The use of adjunctive therapies to achieve rapid recovery from clinical symptoms of acute bronchiolitis would appear necessary. This study was performed to determine the effect of zinc sulphate on treating acute bronchiolitis. In this study, 100 children affected with acute bronchiolitis were investigated. Fifty patients received oral zinc sulphate and 50 patients placebo. Signs and symptoms of the disease were compared between two groups at the time of admission and then 24, 48, 72, 96 and 120 hours after the beginning of treatment. The trend of recovery of clinical signs and symptoms was more favourable in the case group than in the control group in 24, 48, 72, 96 and 120 hours after beginning of the treatment. The significant differences were observed between the two groups in terms of improvements in coughing and wheezing 48 and 72 hours after the beginning of the treatment (P<0.05). Full recovery was observed in 49 (98%) patients receiving zinc sulphate within 72 hours of the beginning of treatment (P=0.0001). The present study showed that administration of zinc sulphate accelerates improvement from clinical signs and symptoms of acute bronchiolitis. Thus we recommend the use of zinc sulphate for the treatment of acute bronchiolitis.
使用辅助疗法以从急性细支气管炎的临床症状中快速恢复似乎是必要的。本研究旨在确定硫酸锌对治疗急性细支气管炎的效果。在本研究中，对100名患有急性细支气管炎的儿童进行了调查。50名患者接受口服硫酸锌，50名患者接受安慰剂。在入院时以及治疗开始后的24、48、72、96和120小时对两组患者的疾病体征和症状进行比较。在治疗开始后的24、48、72、96和120小时，病例组临床体征和症状的恢复趋势比对照组更有利。在治疗开始后的48和72小时，两组在咳嗽和喘息改善方面存在显著差异（P<0.05）。在开始治疗后的72小时内，49名（98%）接受硫酸锌治疗的患者实现了完全康复（P=0.0001）。本研究表明，硫酸锌的给药可加速急性细支气管炎临床体征和症状的改善。因此，我们建议使用硫酸锌治疗急性细支气管炎。
