Moshtagh Mozhgan, Amiri Rana
Social Determinants of Health Research Center, Faculty of Health, Birjand University of Medical Sciences, Birjand,Iran.
Visiting Scholar, Department of Geography and Environmental Sciences, Northumbria University, UK.
Tanaffos. 2020 Jan;19(1):1-9.
Respiratory infectious disease is considered as one of the most serious problems among children in developing countries. The importance of zinc in the improvement of respiratory disease has been indicated. However, there are some unanswered questions and uncertainty. This systematic review aimed at assessing the therapeutic benefits of zinc supplementation on respiratory infections of Iranian children.
Databases, such as PubMed, Scopus, Embase, Magiran, and IranDoc, were searched for randomized controlled trials published from January 1998 to December 2017 on Zinc supplementation for the treatment or improvement of acute respiratory disease among Iranian children, during March 2018. Studies were screened according to the PICO framework, and irrelevant studies were excluded.
A total of 5 studies conducted on 522 children were included in this review. Except for one study, others had indicated the beneficial effect of zinc supplement on improving signs and symptoms of respiratory infectious disease and earlier discharge from the hospital.
Although studies on the efficacy of zinc on respiratory infectious disease of children in Iran have not widely considered and more studies should be conducted, all published articles (except for one of them) had indicated the effectiveness of zinc supplementation on respiratory infections among children. Other criteria, such as age, gender, birth weight, diet, and type of respiratory infections, should be considered during zinc therapy. Controlling these confounding variables and measuring the level of blood zinc are necessary to understand how much zinc should be prescribed for respiratory treatment of children.
呼吸道传染病被认为是发展中国家儿童面临的最严重问题之一。锌在改善呼吸道疾病方面的重要性已得到证实。然而，仍存在一些未解决的问题和不确定性。本系统评价旨在评估补充锌对伊朗儿童呼吸道感染的治疗效果。
2018年3月，检索了PubMed、Scopus、Embase、Magiran和IranDoc等数据库，以查找1998年1月至2017年12月发表的关于补充锌治疗或改善伊朗儿童急性呼吸道疾病的随机对照试验。根据PICO框架对研究进行筛选，排除无关研究。
本评价共纳入了对522名儿童进行的5项研究。除一项研究外，其他研究均表明补充锌对改善呼吸道传染病的体征和症状以及提前出院有有益作用。
尽管关于锌对伊朗儿童呼吸道传染病疗效的研究尚未得到广泛关注，仍需开展更多研究，但所有已发表的文章（其中一项除外）均表明补充锌对儿童呼吸道感染有效。在锌治疗过程中，应考虑年龄、性别、出生体重、饮食和呼吸道感染类型等其他标准。控制这些混杂变量并测量血锌水平对于了解儿童呼吸道治疗应开具多少锌剂是必要的。
