• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers.

作者信息

Lee Ju Hwa, Kim Sung Soo, Kim Min Sung, Yoo Nam Jin, Lee Sug Hyung

机构信息

Departments of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul, 137-701, South Korea.

Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

出版信息

Pathol Oncol Res. 2017 Apr;23(2):451-452. doi: 10.1007/s12253-016-0173-3. Epub 2016 Dec 23.

DOI:10.1007/s12253-016-0173-3
PMID:28012115
Abstract
摘要

相似文献

1
WRN, the Werner Syndrome Gene, Exhibits Frameshift Mutations in Gastric and Colorectal Cancers.沃纳综合征基因（WRN）在胃癌和结直肠癌中存在移码突变。
Pathol Oncol Res. 2017 Apr;23(2):451-452. doi: 10.1007/s12253-016-0173-3. Epub 2016 Dec 23.
2
WRN mutations in Werner syndrome.沃纳综合征中的WRN突变。
Hum Mutat. 1999;13(4):271-9. doi: 10.1002/(SICI)1098-1004(1999)13:4<271::AID-HUMU2>3.0.CO;2-Q.
3
Uncommon cause of cirrhosis-A case of Werner syndrome with a novel WRN mutation.肝硬化的罕见病因——一例伴有新型WRN突变的沃纳综合征病例
Indian J Gastroenterol. 2017 Jul;36(4):323-325. doi: 10.1007/s12664-017-0781-1. Epub 2017 Aug 9.
4
Comparative aspects of the Werner syndrome gene.沃纳综合征基因的比较方面。
In Vivo. 2000 Jan-Feb;14(1):165-72.
5
Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome.一名患有沃纳综合征的患者中枢神经系统中缺乏淀粉样斑块形成。
Neuropathology. 2003 Mar;23(1):51-6. doi: 10.1046/j.1440-1789.2003.00474.x.
6
Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C.具有新型复合杂合WRN突变c.1720+1G>A加c.3139-1G>C的沃纳综合征的特征性临床特征
Intern Med. 2019 Apr 1;58(7):1033-1036. doi: 10.2169/internalmedicine.1816-18. Epub 2018 Dec 18.
7
Preferential expression of an intact WRN gene in Werner syndrome cell lines in which a normal chromosome 8 has been introduced.在已导入正常8号染色体的沃纳综合征细胞系中完整WRN基因的优先表达。
Biochem Biophys Res Commun. 2001 Nov 23;289(1):111-5. doi: 10.1006/bbrc.2001.5933.
8
Possible associations between successful aging and polymorphic markers in the Werner gene region.沃纳基因区域中成功衰老与多态性标记之间的可能关联。
Ann N Y Acad Sci. 2006 May;1067:309-10. doi: 10.1196/annals.1354.041.
9
[Chart no 45 - WRN (RCQL3)].
Bull Cancer. 2001 Jun;88(6):537-8.
10
The Werner syndrome protein: an update.沃纳综合征蛋白：最新进展。
Bioessays. 2000 Oct;22(10):894-901. doi: 10.1002/1521-1878(200010)22:10<894::AID-BIES4>3.0.CO;2-B.

引用本文的文献

1
Germline Mutation Is the Likely Inherited Etiology of Various Cancer Types in One Iranian Family.种系突变可能是一个伊朗家庭中多种癌症类型的遗传病因。
Front Oncol. 2021 Jun 7;11:648649. doi: 10.3389/fonc.2021.648649. eCollection 2021.
2
Human RecQ Helicases in DNA Double-Strand Break Repair.DNA双链断裂修复中的人类RecQ解旋酶
Front Cell Dev Biol. 2021 Feb 25;9:640755. doi: 10.3389/fcell.2021.640755. eCollection 2021.

本文引用的文献

1
Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity.基于肿瘤内遗传异质性的原发性和转移性结直肠癌的亚克隆基因组结构。
Clin Cancer Res. 2015 Oct 1;21(19):4461-72. doi: 10.1158/1078-0432.CCR-14-2413. Epub 2015 May 15.
2
Regional Bias of Intratumoral Genetic Heterogeneity of Apoptosis-Related Genes BAX, APAF1, and FLASH in Colon Cancers with High Microsatellite Instability.高微卫星不稳定性结肠癌中凋亡相关基因BAX、APAF1和FLASH的肿瘤内遗传异质性的区域偏倚
Dig Dis Sci. 2015 Jun;60(6):1674-9. doi: 10.1007/s10620-014-3499-2. Epub 2015 Jan 20.
3
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
沃纳综合征基因产物解旋酶在致癌作用及癌细胞对基因毒素的抗性中的作用。
Cancer Sci. 2008 May;99(5):843-8. doi: 10.1111/j.1349-7006.2008.00778.x. Epub 2008 Feb 26.
4
Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.致癌作用与微卫星不稳定性：遗传学与表观遗传学之间的相互关系。
Carcinogenesis. 2008 Apr;29(4):673-80. doi: 10.1093/carcin/bgm228. Epub 2007 Oct 17.
5
Molecular biology of Werner syndrome.沃纳综合征的分子生物学
Int J Clin Oncol. 2004 Aug;9(4):288-98. doi: 10.1007/s10147-004-0426-0.
6
Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases.布鲁姆综合征和沃纳综合征基因抑制酵母sgs1突变体中的过度重组：对人类疾病基因组不稳定性的影响。
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8733-8. doi: 10.1073/pnas.95.15.8733.
7
Excess of rare cancers in Werner syndrome (adult progeria).沃纳综合征（成人早衰症）中罕见癌症的过量发生。
Cancer Epidemiol Biomarkers Prev. 1996 Apr;5(4):239-46.