Ogden Sally, Harave Srikrishna, McPartland Jo, Brennan Bernadette, Jeys Lee, Losty Paul, Pizer Barry
Department of Oncology, Alder Hey Children's Hospital, Liverpool, Merseyside, UK.
Department of Oncology, Royal Manchester Children's Hospital, Manchester, UK.
Pediatr Blood Cancer. 2017 Jun;64(6). doi: 10.1002/pbc.26376. Epub 2016 Dec 24.
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumour with intermediate malignant potential. We report the case of a patient with local recurrence of AFH in two locations and lymph node metastases 18 months after primary surgical excision. The patient was treated with six cycles of ifosfamide and doxorubicin chemotherapy and a further three courses of ifosfamide monotherapy. Reassessment imaging showed a good response to chemotherapy with reduction in size of the two tumours of local recurrence and the lymph node metastases. This case demonstrates that AFH can respond to chemotherapy, even though it is rarely used.
血管样纤维组织细胞瘤（AFH）是一种具有潜在中度恶性的罕见软组织肿瘤。我们报告了一例患者，在初次手术切除18个月后，AFH在两个部位出现局部复发并伴有淋巴结转移。该患者接受了六个周期的异环磷酰胺和阿霉素化疗以及另外三个疗程的异环磷酰胺单药治疗。重新评估的影像学检查显示化疗反应良好，局部复发的两个肿瘤以及淋巴结转移灶的大小均有所减小。该病例表明，AFH对化疗有反应，尽管化疗很少用于该肿瘤。
