Robben Joris Henricus, Dijkman Marieke Annet
Intensive Care Unit, Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.154, Utrecht NL-3584 CM, The Netherlands.
Dutch Poisons Information Center, Division of Anesthesiology, Intensive Care and Emergency Medicine, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
Vet Clin North Am Small Anim Pract. 2017 Mar;47(2):435-450. doi: 10.1016/j.cvsm.2016.10.018. Epub 2016 Dec 21.
This review discusses the use of intravenous lipid emulsion (ILE) in the treatment of intoxications with lipophilic agents in veterinary medicine. Despite growing scientific evidence that ILE has merit in the treatment of certain poisonings, there is still uncertainty on the optimal composition of the lipid emulsion, the dosing, the mechanism of action, and the efficacy. Therefore, a critical view of the clinician on the applicability of this modality in intoxications is still warranted. The use of ILE therapy is advocated as an antidote in cases of intoxications with some lipophilic substances.
本综述讨论了静脉注射脂质乳剂（ILE）在兽医学中用于治疗亲脂性药物中毒的情况。尽管越来越多的科学证据表明ILE在治疗某些中毒方面具有价值，但在脂质乳剂的最佳组成、给药剂量、作用机制和疗效方面仍存在不确定性。因此，临床医生对这种治疗方式在中毒中的适用性仍需持批判性观点。在某些亲脂性物质中毒的情况下，提倡使用ILE疗法作为解毒剂。
