Johansen Sys Stybe
Section of Forensic Chemistry, Department of Forensic Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Frederik V's vej 11, DK-2100, Denmark.
Forensic Sci Int. 2017 Jan;270:e12-e15. doi: 10.1016/j.forsciint.2016.12.010. Epub 2016 Dec 15.
A drug rape facilitated with the sedative antipsychotic drug quetiapine is presented here. A teenage girl and her girlfriend went to the home of an adult couple they had met at a bar. Here, the teenage girl (victim) felt tired after consuming some alcoholic drinks and fell asleep. While she was asleep, the others left her at the house alone and returned to the bar. Later, the girl woke up to witness the adult male having intercourse with her, but she was not able to resist the attack. She fell asleep again and slept through the next day and a half, after which she left the house. Forty-three hours after the suspected drug-facilitated sexual assault (DFSA), blood and urine samples were collected and the initial toxicological screening detected quetiapine. Confirmation and quantification by ultra high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) revealed a concentration of 0.007mg/kg quetiapine in blood and 0.19mg/l in urine. Six months after the DFSA, a hair sample was collected and segmental hair analysis was performed on four washed segments (0-3cm, 3-5cm, 5-7cm, and 7-9cm). The last segment contained 0.011ng/mg of quetiapine, whereas the other segments were negative. The low level of quetiapine in the hair segment and its absence in the other segments indicate that the victim had only consumed one or a few doses of quetiapine within that period and was not a regular user. This study describes the first drug-facilitated assault involving a single dose of quetiapine that was detected by hair, blood and urine analysis. This case illustrates the importance of having very sensitive analytical methods for measurement of a single dose in blood and urine and how the extended detection window for hair analysis can reveal more information in such cases.
本文介绍了一起利用镇静性抗精神病药物喹硫平实施的药物协助强奸案。一名少女和她的女友前往她们在酒吧结识的一对成年夫妇家中。在此，少女（受害者）喝了一些酒精饮料后感到疲倦并入睡。她睡着时，其他人将她独自留在屋内，然后返回了酒吧。后来，女孩醒来目睹成年男性与她发生性关系，但她无法抵抗此次袭击。她再次入睡，一觉睡了一天半，之后才离开那所房子。在疑似药物协助性侵犯（DFSA）发生43小时后，采集了血液和尿液样本，初步毒理学筛查检测到了喹硫平。通过超高效液相色谱-串联质谱联用（UHPLC-MS/MS）进行的确认和定量分析显示，血液中喹硫平浓度为0.007mg/kg，尿液中为0.19mg/l。DFSA发生六个月后，采集了一份毛发样本，并对四个清洗过的毛发段（0-3cm、3-5cm、5-7cm和7-9cm）进行了分段毛发分析。最后一段毛发中含有0.011ng/mg的喹硫平，而其他段均为阴性。毛发段中喹硫平含量较低且其他段未检出，这表明受害者在那段时间内仅服用了一剂或几剂喹硫平，并非经常使用者。本研究描述了首例通过毛发、血液和尿液分析检测到单剂量喹硫平的药物协助性侵犯案件。该案例说明了拥有非常灵敏的分析方法来测量血液和尿液中的单剂量药物的重要性，以及毛发分析的延长检测窗口如何能在此类案件中揭示更多信息。
