非编码 RNA 作为抗生素靶点。

Non-coding RNAs as antibiotic targets.

机构信息

Department of Biology and Institute for Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada.

出版信息

Biochem Pharmacol. 2017 Jun 1;133:29-42. doi: 10.1016/j.bcp.2016.12.015. Epub 2016 Dec 22.

DOI:10.1016/j.bcp.2016.12.015

PMID:28012959

Abstract

Antibiotics inhibit a wide range of essential processes in the bacterial cell, including replication, transcription, translation and cell wall synthesis. In many instances, these antibiotics exert their effects through association with non-coding RNAs. This review highlights many classical antibiotic targets (e.g. rRNAs and the ribosome), explores a number of emerging targets (e.g. tRNAs, RNase P, riboswitches and small RNAs), and discusses the future directions and challenges associated with non-coding RNAs as antibiotic targets.

摘要

抗生素抑制细菌细胞中的许多基本过程，包括复制、转录、翻译和细胞壁合成。在许多情况下，这些抗生素通过与非编码 RNA 结合发挥作用。本文重点介绍了许多经典的抗生素靶标（如 rRNA 和核糖体），探讨了一些新出现的靶标（如 tRNA、RNase P、核糖体开关和小 RNA），并讨论了非编码 RNA 作为抗生素靶标相关的未来方向和挑战。