Aleksandrovych Veronika, Sajewicz Marek, Walocha Jerzy A, Gil Krzysztof
Department of Pathophysiology, Jagiellonian University, Medical College, Kraków, Poland.
Folia Med Cracov. 2016;56(2):17-23.
Infertility is actually widespread pathological condition, which affected one in every four couples in developing countries. Approximately one third of all cases are connected with tubal factor infertility, o en accompanies by endometriosis, acute salpingitis, urogenital infections etc. The newly identified telocytes (TCs) have multiple potential bio-functions and might participate in the fertility problems. They influence on structural and functional integrity of oviduct tissue. Despite recent discovery, TCs involvement in the majority of physiological and pathological processes is still unclear and require significant increasing of deep observations and data analysis. Focusing on female reproductive system help better understands the main reasons of infertility, while evaluation of TCs impact on Fallopian tube and uterus contractility might be a key point of its correction. The article summarizes the main features of telocytes in Fallopian tubes, emphasizing their involvement in pathophysiological processes and tubal factor infertility.
不孕症实际上是一种普遍存在的病理状况,在发展中国家,每四对夫妇中就有一对受其影响。所有病例中约有三分之一与输卵管因素不孕症有关,常伴有子宫内膜异位症、急性输卵管炎、泌尿生殖系统感染等。新发现的间充质干细胞(TCs)具有多种潜在生物功能,可能与生育问题有关。它们影响输卵管组织的结构和功能完整性。尽管最近有相关发现,但间充质干细胞在大多数生理和病理过程中的作用仍不清楚,需要大量深入观察和数据分析。关注女性生殖系统有助于更好地理解不孕的主要原因,而评估间充质干细胞对输卵管和子宫收缩性的影响可能是纠正不孕的关键。本文总结了输卵管中间充质干细胞的主要特征,强调了它们在病理生理过程和输卵管因素不孕症中的作用。