吲哚美辛对软骨破坏的影响。
The effect of indomethacin on cartilage breakdown.
作者信息
Desa F M, Chander C L, Moore A R, Howat D W, Corry D G, Willoughby D A
机构信息
Department of Experimental Pathology, St. Bartholomew's Hospital, Medical College, London, UK.
出版信息
Agents Actions. 1989 Jun;27(3-4):485-7. doi: 10.1007/BF01972859.
The effects of recombinant interleukin-1 alpha (rIL-1 alpha) and indomethacin on the glycosaminoglycan (GAG) content of rat femoral head cartilage (FHC) were studied in vitro. Net GAG loss was observed from cartilage cultured in the presence of indomethacin plus rIL-1 alpha. Indomethacin and rIL-1 alpha alone caused no net loss of GAG from cartilage unless the cartilage was cultured in the presence of fibroblasts.
在体外研究了重组白细胞介素-1α（rIL-1α）和吲哚美辛对大鼠股骨头软骨（FHC）中糖胺聚糖（GAG）含量的影响。在吲哚美辛加rIL-1α存在的情况下培养的软骨中观察到GAG净损失。单独使用吲哚美辛和rIL-1α不会导致软骨中GAG的净损失，除非软骨在成纤维细胞存在的情况下培养。
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