Fukuda S, Kogure M, Shimakawa M, Wakatsuki Y, Takahashi Y, Ohsone T, Oguro Y, Kanai K, Kuranami T
Nippon Ganka Gakkai Zasshi. 1989 Apr;93(4):412-7.
In Caucasians, there is close correlation between acute anterior uveitis and histocompatibility antigen HLA-B27. But in Japanese, this is not clear. Therefore, we examined 58 patients with non-granulomatous anterior uveitis (NGAU) about HLA typing in our uveitis clinic at Tokyo Women's Medical College Hospital. HLA-B27 was identified in 20 out of 58 patients (34.5%) with NGAU and it was statistically significant. We also studied the clinical features of patients with HLA-B27 positive NGAU. We found that in HLA-B27-positive NGAU, the visual acuity was more strongly affected during the attack and the duration of inflammation was longer than HLA-B27 negative NGAU patients. The duration of the first attack was longer than re-attack, and the duration of the first attack was longer than HLA-B27 negative NGAU patients. It was less commonly associated with systemic disorders in Japanese HLA-B27 positive anterior uveitis than in Caucasian. However, in Japanese NGAU patients without systemic disorders, there was the same tendency concerning the HLA-B27 positive rate as in Caucasians.
在白种人中，急性前葡萄膜炎与组织相容性抗原HLA - B27之间存在密切关联。但在日本人中，这种关联并不明确。因此，我们在东京女子医科大学医院的葡萄膜炎门诊，对58例非肉芽肿性前葡萄膜炎（NGAU）患者进行了HLA分型检测。58例NGAU患者中有20例（34.5%）检测出HLA - B27，具有统计学意义。我们还研究了HLA - B27阳性NGAU患者的临床特征。我们发现，在HLA - B27阳性的NGAU中，发作期间视力受影响更严重，炎症持续时间比HLA - B27阴性的NGAU患者更长。首次发作的持续时间比再次发作更长，且首次发作的持续时间比HLA - B27阴性的NGAU患者更长。与白种人相比，日本HLA - B27阳性前葡萄膜炎患者与全身性疾病的关联较少。然而，在无全身性疾病的日本NGAU患者中，HLA - B27阳性率与白种人有相同的趋势。
