Abiltayeva Aizhan, Moore Malcolm Anthony, Myssayev Ayan, Adylkhanov Tasbolat, Baissalbayeva Ainur, Zhabagin Kuantkan, Beysebayev Eldar
Semey State Medical University, Semey,Kazakhstan. Email:
Asian Pac J Cancer Prev. 2016 Oct 1;17(10):4797-4802. doi: 10.22034/apjcp.2016.17.10.4797.
Background: Breast cancer (BC) is the top cancer among women worldwide and has been the most frequent malignancy among Kazakhstan women over the past few decades. Information on clinical and histopathological features of metastatic breast cancer (MBC), as well as the distribution of molecular subtypes is limited for Kazakh people. Materials and Methods: The present observational retrospective study was carried out at Regional Oncologic Dispensaries in the North-East Region of Kazakhstan (in Semey and Pavlodar cities). Сlinical and histopathological data were obtained for a total of 570 MBC patients in the 10 year period from 2004-2013, for whom data on molecular subtype were available for 253. Data from hospital charts were entered into SPSS 20 for analysis by one-way ANOVA analysis of associations of different variables with 1-5 year survival. Pearson correlation and linear regression models were used to examine the relation between parameters with a p-value < 0.05 considered statistically significant. Results: No significant relationships were evident between molecular subtype and survival, site of metastases, stage or ethnicity. Young females below the age of 44 were slightly more likely to have triple negative lesions. While the ductal type greatly predomonated, luminal A and B cases had a higher percentage with lobular morphology. Conclusions: In this select group of metastatice brease cancer, no links were noted for survival with molecular subtype, in contrast to much of the literature.
背景:乳腺癌是全球女性中最常见的癌症,在过去几十年中一直是哈萨克斯坦女性中最常见的恶性肿瘤。关于转移性乳腺癌(MBC)的临床和组织病理学特征以及分子亚型分布的信息,对于哈萨克人群来说是有限的。 材料与方法:本观察性回顾性研究在哈萨克斯坦东北部地区(塞米伊市和巴甫洛达尔市)的地区肿瘤防治所进行。收集了2004年至2013年这10年间共570例MBC患者的临床和组织病理学数据,其中253例患者有分子亚型数据。将医院病历数据录入SPSS 20,通过单因素方差分析不同变量与1至5年生存率的关联进行分析。采用Pearson相关性分析和线性回归模型来检验参数之间的关系,p值<0.05被认为具有统计学意义。 结果:分子亚型与生存率、转移部位、分期或种族之间未发现明显的显著关系。44岁以下的年轻女性患三阴性病变的可能性略高。虽然导管型占主导,但管腔A型和B型病例中具有小叶形态的比例更高。 结论:在这组转移性乳腺癌患者中,与许多文献相反,未发现分子亚型与生存率之间存在关联。
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