Takahashi S, Ozono S, Cho M, Fujimoto K, Sasaki K, Hirao Y, Okajima E
Department of Urology, Nara Medical University.
Hinyokika Kiyo. 1989 Jun;35(6):1055-9.
A case of metastasis to the penis and the urethra from superficial bladder tumor of transitional cell carcinoma (TCC), grade 3 is reported. A 52-year-old male patient was diagnosed to have TCC of the urinary bladder (grade 3, stage pT1a) in May, 1985 and was treated initially with transurethral resection followed by adriamycin (ADR) instillation. In February, 1986, urethroscopy showed a papillary tumor in the cavernosal urethra and a metastatic tumor was noted in the corpus spongiosum penis. Biopsy of urethral tumor revealed TCC, grade 3. Therefore partial urethrectomy with resection of penile tumor was performed. Although the patient underwent combination chemotherapy involving CAP (cisplatin + ADR + cyclophosphamide) and M-VAC (methotrexate + vincristine + ADR + cisplatin) regimens, local lesion and metastatic lesions progressed, and he died in June 1986, 20 days after emasculation. The management of superficial bladder tumor with TCC, grade 3 was reviewed and discussed here.
本文报告一例3级移行细胞癌浅表性膀胱肿瘤转移至阴茎和尿道的病例。一名52岁男性患者于1985年5月被诊断为膀胱移行细胞癌（3级，pT1a期），最初接受经尿道切除术，随后膀胱内灌注阿霉素（ADR）。1986年2月，尿道镜检查发现海绵体尿道有乳头状肿瘤，阴茎海绵体有转移瘤。尿道肿瘤活检显示为3级移行细胞癌。因此，行部分尿道切除术并切除阴茎肿瘤。尽管患者接受了包括CAP（顺铂+阿霉素+环磷酰胺）和M-VAC（甲氨蝶呤+长春新碱+阿霉素+顺铂）方案的联合化疗，但局部病变和转移病变仍进展，患者于1986年6月去势后20天死亡。本文对3级移行细胞癌浅表性膀胱肿瘤的治疗进行了回顾和讨论。
