Nagata Y, Tanaka M, Nakajima N, Tanikawa K, Matsushita K
Department of Urology, Tokai University, Tokyo Hospital.
Hinyokika Kiyo. 1988 Jun;34(6):1043-6.
A 42-year-old male was admitted to our Hospital. Diagnosis of invasive bladder cancer was made and a total cystectomy was carried out on September 14, 1982. Histological examination showed transitional cell carcinoma, grade II-III, pT2N0M0. After cystectomy, the patient was treated with a combination chemotherapy of cis-platinum, cyclophosphamide, adriamycin and 5-fluorouracil. After 3 years, he noticed an area of reddish and painless rashes around the urethral meatus. A biopsy of the skin lesion showed a nest formation of transitional cell carcinoma with lymphocyte infiltration under the squamous epithelium. A urethrectomy was carried out on January, 28, 1986. A histologic study established the diagnosis of recurrent transitional cell carcinoma. The pathological process seemed to be a result of hematogenous metastasis rather than multicentricity or implantation.
一名42岁男性入住我院。诊断为浸润性膀胱癌,并于1982年9月14日行全膀胱切除术。组织学检查显示为移行细胞癌,II-III级,pT2N0M0。膀胱切除术后,患者接受了顺铂、环磷酰胺、阿霉素和5-氟尿嘧啶的联合化疗。3年后,他注意到尿道口周围有一片发红且无痛的皮疹区域。皮肤病变活检显示鳞状上皮下有移行细胞癌巢形成并伴有淋巴细胞浸润。1986年1月28日行尿道切除术。组织学研究确诊为复发性移行细胞癌。病理过程似乎是血行转移的结果,而非多中心性或种植性转移。