Dagnelie P C, van Staveren W A, Vergote F J, Dingjan P G, van den Berg H, Hautvast J G
Department of Human Nutrition, Wageningen Agricultural University, The Netherlands.
Am J Clin Nutr. 1989 Oct;50(4):818-24. doi: 10.1093/ajcn/50.4.818.
The blood iron, vitamin B-12, and folate status of the 1985 birth cohort of Dutch infants aged 10.1-20.4 mo fed macrobiotic diets (n = 50) and matched omnivorous control infants (n = 57) was measured. Fe deficiency (combination of Hb less than 120 g/L, ferritin less than 12 micrograms/L, and FEP greater than 1.77 mumol/L) was observed in 15% of the macrobiotic group but not in the control group (p = 0.003). Plasma vitamin B-12 concentrations in the macrobiotic group were far below those of the control group (geometrical mean: 149 and 404 pmol/L, respectively, p less than 0.001). Plasma folate concentrations were higher in the macrobiotic group (31.6 +/- 11.7 nmol/L) than in the control group (21.1 +/- 8.8 nmol/L, p less than 0.001). In the macrobiotic group mean corpuscular volume, mean corpuscular hemoglobin mass, and mean corpuscular hemoglobin concentration were higher and hematocrit and red blood cells were lower (all p less than 0.05) than in the control group. It is advised to incorporate regular servings of animal foods into the macrobiotic diet to obtain an adequate amount of vitamin B-12.
对10.1至20.4个月大的荷兰婴儿1985年出生队列中采用素食饮食的婴儿（n = 50）以及匹配的杂食性对照婴儿（n = 57）的血铁、维生素B - 12和叶酸状况进行了测量。素食组中15%的婴儿出现缺铁情况（血红蛋白低于120 g/L、铁蛋白低于12微克/L且游离原卟啉大于1.77微摩尔/L），而对照组未出现（p = 0.003）。素食组的血浆维生素B - 12浓度远低于对照组（几何平均值分别为149和404 pmol/L，p < 0.001）。素食组的血浆叶酸浓度高于对照组（31.6 ± 11.7 nmol/L）（对照组为21.1 ± 8.8 nmol/L，p < 0.001）。与对照组相比，素食组的平均红细胞体积、平均红细胞血红蛋白量和平均红细胞血红蛋白浓度更高，而血细胞比容和红细胞更低（所有p < 0.05）。建议在素食饮食中定期加入动物性食物，以获取足够量的维生素B - 12。
