Makino M, Kaibara N, Kimura O, Nishidoi H, Koga S
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
Am J Clin Oncol. 1989 Oct;12(5):407-10. doi: 10.1097/00000421-198910000-00009.
We have examined the correlation between the depth of venous invasion of the gastric wall and the occurrence of liver metastasis in cases of gastric cancer. In 244 patients examined, the incidence of venous invasion, and in particular of subserosal venous invasion, was appreciably high in cases of poorly differentiated adenocarcinoma of the medullary type. Synchronous and metachronous liver metastases were found in 13 and 18 patients, respectively. In these cases, poorly differentiated adenocarcinoma with a medullary growth pattern was the most frequent, and papillary adenocarcinoma was the next most frequent type of cancer. The incidence of liver metastases was appreciably higher in patients with subserosal venous invasion than in those with only submucosal venous invasion. Considering the above observations, we posit that subserosal venous invasion by cancer, especially by poorly differentiated adenocarcinoma of the medullary type, is indicative of the risk for development of liver metastasis in patients with gastric cancer.
我们研究了胃癌病例中胃壁静脉侵犯深度与肝转移发生之间的相关性。在接受检查的244例患者中，髓样型低分化腺癌病例的静脉侵犯发生率，尤其是浆膜下静脉侵犯发生率明显较高。分别在13例和18例患者中发现了同时性和异时性肝转移。在这些病例中，具有髓样生长模式的低分化腺癌最为常见，乳头状腺癌是其次常见的癌症类型。浆膜下静脉侵犯患者的肝转移发生率明显高于仅黏膜下静脉侵犯的患者。考虑到上述观察结果，我们认为癌症的浆膜下静脉侵犯，尤其是髓样型低分化腺癌的浆膜下静脉侵犯，表明胃癌患者发生肝转移的风险。
