Kaibara N, Kimura O, Nishidoi H, Makino M, Kawasumi H, Koga S
J Surg Oncol. 1985 Mar;28(3):195-8. doi: 10.1002/jso.2930280310.
We studied the histology of resected specimens from 71 gastric cancer patients with synchronous and metachronous liver metastasis to assess the predominance of a particular histological pattern in gastric cancer with a tendency for liver metastasis. Poorly differentiated adenocarcinoma manifesting a medullary growth pattern was the most frequent histologic pattern (33%), followed by papillary adenocarcinoma (28%) in 39 patients with synchronous liver metastasis. In 32 patients who developed metachronous liver metastasis as the main pattern of recurrence, papillary adenocarcinoma was most frequent (47%), followed by poorly differentiated adenocarcinoma of the medullary type (28%). Scirrhous carcinoma was not encountered in patients manifesting metachronous liver metastasis. As most of the papillary adenocarcinomas exhibited a medullary growth pattern, we hypothesize that gastric cancer of the medullary type tends to metastasize to the liver, irrespective of the basic histologic pattern, and that poorly differentiated adenocarcinoma of the medullary type has a particularly high tendency for metastasizing to the liver.
我们研究了71例伴有同时性和异时性肝转移的胃癌患者切除标本的组织学，以评估在有肝转移倾向的胃癌中特定组织学模式的优势。表现为髓样生长模式的低分化腺癌是最常见的组织学模式（33%），在39例同时性肝转移患者中，其次是乳头状腺癌（28%）。在32例以异时性肝转移为主要复发模式的患者中，乳头状腺癌最常见（47%），其次是髓样型低分化腺癌（28%）。在表现为异时性肝转移的患者中未遇到硬癌。由于大多数乳头状腺癌表现为髓样生长模式，我们推测，无论基本组织学模式如何，髓样型胃癌都倾向于转移至肝脏，并且髓样型低分化腺癌转移至肝脏的倾向特别高。
