Wang L, Hu X-H, Huang Z-X, Nie Q, Chen Z-G, Xiang J-W, Qi R-L, Yang T-H, Xiao Y, Qing W-J, Gigantelli G, Nguyen Q D, Li D W-C
Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198- 5540,. United States.
Curr Mol Med. 2017;16(10):885-892. doi: 10.2174/1566524016666161223110106.
CREB is an ubiquitous transcription factor regulating diverse cellular responses. Its phosphorylation at S133 is an essential event for its activation in both nervous and visual systems. The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system. Moreover, sumoylation, an important post-translational modification of protein, plays a key role in sustaining CREB activation in the rat hippocampus in order to enhance the long-term memory and other aspects. In the visual system, although the CREB activation by phosphorylation at S133 is similar to that as observed in the nervous system, the role of CREB sumoylation remains to be explored. This review will discuss the aspects of CREB functions and their regulation by phosphorylation and sumoylation in both systems.
CREB是一种普遍存在的转录因子，可调节多种细胞反应。其在S133位点的磷酸化是其在神经和视觉系统中激活的关键事件。活化的CREB参与神经系统发育、保护、学习、记忆和可塑性的调节。此外，蛋白质的重要翻译后修饰——SUMO化，在维持大鼠海马体中CREB的激活以增强长期记忆及其他方面发挥关键作用。在视觉系统中，虽然S133位点磷酸化导致的CREB激活与在神经系统中观察到的相似，但CREB SUMO化的作用仍有待探索。本综述将讨论这两个系统中CREB功能及其通过磷酸化和SUMO化调节的相关方面。
