You Shoujiang, Zhong Chongke, Zheng Danni, Xu Jiaping, Zhang Xia, Liu Huihui, Zhang Yanlin, Shi Jijun, Huang Zhichao, Cao Yongjun, Liu Chun-Feng
Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China.
J Neurol Sci. 2017 Jan 15;372:157-161. doi: 10.1016/j.jns.2016.11.022. Epub 2016 Nov 12.
Monocyte and monocyte to high-density lipoprotein ratio (MHR) recently emerged as markers of inflammation and have been reported to be novel prognostic indicators of cardiovascular diseases. We investigated the association of monocyte and MHR with hospital discharge and 3-month outcome after acute intracerebral hemorrhage (ICH).
A total of 316 patients with acute ICH were enrolled from November 2011 to March 2014. Demographic characteristics, lifestyle risk factors, medical history, admission laboratory parameters, and monocyte level were recorded. Clinical outcome was disability or death (defined as having a modified Rankin Scale score≥2) upon discharge or at 3months.
202 patients (63.9%) experienced disability or death at hospital discharge, and 176 patients (55.7%) at 3months post-ICH. Admission monocyte level was associated with clinical outcome at 3months (adjusted OR, 4.17; 95% CI, 1.45-12.00; P-trend=0.028) when highest and lowest quartiles were compared. However, no significant association was found between monocyte and discharge outcome (P-trend=0.102). Compared to the lowest category of MHR, the highest category was associated with a 3.87-fold increase in the odds of disability or death at discharge (95% CI, 1.17-12.76; P-trend=0.045) and 3.08-fold increased odds of disability or death at 3-month (95% CI, 1.05-9.08; P-trend=0.024).
In patients with acute ICH, higher MHR was associated with increased risk of disability or death at discharge and at 3months post-ICH, however higher monocyte was only associated with increased risk of 3-month disability or death.
单核细胞及单核细胞与高密度脂蛋白比值（MHR）最近成为炎症标志物，并据报道是心血管疾病的新型预后指标。我们研究了单核细胞及MHR与急性脑出血（ICH）后出院情况及3个月预后的相关性。
2011年11月至2014年3月共纳入316例急性ICH患者。记录人口统计学特征、生活方式危险因素、病史、入院实验室参数及单核细胞水平。临床结局为出院时或3个月时的残疾或死亡（定义为改良Rankin量表评分≥2）。
202例患者（63.9%）出院时出现残疾或死亡，176例患者（55.7%）在ICH后3个月出现残疾或死亡。比较最高和最低四分位数时，入院单核细胞水平与3个月时的临床结局相关（校正比值比，4.17；95%可信区间，1.45 - 12.00；P趋势 = 0.028）。然而，未发现单核细胞与出院结局之间存在显著相关性（P趋势 = 0.102）。与最低MHR类别相比，最高类别与出院时残疾或死亡几率增加3.87倍相关（95%可信区间，1.17 - 12.76；P趋势 = 0.045），与3个月时残疾或死亡几率增加3.08倍相关（95%可信区间，1.05 - 9.08；P趋势 = 0.024）。
在急性ICH患者中，较高的MHR与出院时及ICH后3个月残疾或死亡风险增加相关，然而较高的单核细胞仅与3个月时残疾或死亡风险增加相关。
