Department of Cardiology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi Province, 530000, China.
BMC Public Health. 2023 Dec 19;23(1):2541. doi: 10.1186/s12889-023-17447-0.
The monocytes to high-density lipoprotein cholesterol ratio (MHR) has been identified as a potential biomarker for cardiovascular and cerebrovascular diseases. In this population-based cross-sectional study, we explored the relationships among carotid artery disease (CAD), including the presence of carotid atherosclerotic plaque (CAP) and carotid artery intima-media thickness (CIMT), the MHR, and related parameter changes.
This cross-sectional study, Conducted from April to June 2019 in a rural area of Tianjin, involved middle-aged and elderly participants. Based on carotid ultrasound examinations, participants were divided into CAP and non-CAP groups. Logistic regression and Receiver Operating Characteristic (ROC) curve analyses were utilized to assess MHR's predictive value for CAP. Gender-specific analyses were also performed to examine predictive variations. The relationship between CIMT and MHR was evaluated using linear regression.
Of the 2109 participants meeting the inclusion criteria, 51.6% were identified with CAP. Multivariate analysis revealed a significant association between MHR and CAP prevalence, (OR, 9.670; 95% CI, 2.359-39.631; P = 0.002), particularly in females (OR, 5.921; 95% CI, 1.823-19.231; P = 0.003), after adjusting for covariates. However, no significant correlation was found between CIMT and MHR when adjusted for other factors. The ROC analysis showed the area under the curve for MHR and CAP to be 0.569 (95% CI: 0.544-0.593; P < 0.001).
These findings suggested that it is crucial to enhance early screening and intervention for CAD, specifically focusing on the prevention and progression of CAP, to address the unique health challenges faced by low-income groups in rural settings. Emphasizing these preventive measures could significantly contribute to improving cardiovascular health outcomes in this vulnerable population.
单核细胞与高密度脂蛋白胆固醇比值（MHR）已被确定为心血管和脑血管疾病的潜在生物标志物。在这项基于人群的横断面研究中，我们探讨了颈动脉疾病（CAD），包括颈动脉粥样硬化斑块（CAP）和颈动脉内-中膜厚度（CIMT）之间的关系，以及 MHR 和相关参数的变化。
这项横断面研究于 2019 年 4 月至 6 月在天津市的一个农村地区进行，纳入了中年和老年人参与者。根据颈动脉超声检查，参与者分为 CAP 和非 CAP 组。采用逻辑回归和受试者工作特征（ROC）曲线分析评估 MHR 对 CAP 的预测价值。还进行了性别特异性分析，以检查预测的变化。采用线性回归评估 CIMT 与 MHR 之间的关系。
在符合纳入标准的 2109 名参与者中，有 51.6%的人患有 CAP。多变量分析显示，MHR 与 CAP 患病率之间存在显著关联（OR，9.670；95%CI，2.359-39.631；P=0.002），尤其是在女性中（OR，5.921；95%CI，1.823-19.231；P=0.003），在调整了协变量后。然而，当调整其他因素时，CIMT 与 MHR 之间没有显著相关性。ROC 分析显示，MHR 和 CAP 的曲线下面积为 0.569（95%CI：0.544-0.593；P<0.001）。
这些发现表明，对于低收入农村地区的人群，必须加强对 CAD 的早期筛查和干预，特别是要关注 CAP 的预防和进展。强调这些预防措施对于改善该脆弱人群的心血管健康结局具有重要意义。
