Clifton V L, Cuffe J, Moritz K M, Cole T J, Fuller P J, Lu N Z, Kumar S, Chong S, Saif Z
Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
School of Medical Science, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia.
Placenta. 2017 Jun;54:24-29. doi: 10.1016/j.placenta.2016.12.017. Epub 2016 Dec 19.
The physiological mechanisms that confer different outcomes in morbidity and mortality of the fetus exposed to stressful environments may be driven by significant differences in the expression and function of the placental glucocorticoid receptor (GR). The recent discovery that the placenta contains at least 8 different isoforms of the GR raises questions about the regulation and physiological relevance of the many GR variants expressed in the placenta. The current data also highlights that individual differences in glucocorticoid sensitivity, variations in the effect of different complications of pregnancy on birth outcomes and sex differences in the response to stress, may all be dependent on a specific GR isoform expression profile. This review will investigate the current state of knowledge of GR isoforms in the placenta and discuss the potential role of these multiple isoforms in regulating glucocorticoid sensitivity.
暴露于应激环境下的胎儿在发病率和死亡率方面出现不同结果的生理机制，可能是由胎盘糖皮质激素受体（GR）表达和功能的显著差异所驱动的。最近发现胎盘含有至少8种不同的GR亚型，这引发了关于胎盘中表达的多种GR变体的调控及其生理相关性的问题。目前的数据还突出表明，糖皮质激素敏感性的个体差异、妊娠不同并发症对出生结局影响的差异以及应激反应中的性别差异，可能都取决于特定的GR亚型表达谱。本综述将研究胎盘中GR亚型的现有知识状态，并讨论这些多种亚型在调节糖皮质激素敏感性方面的潜在作用。
