Centre of Postgraduate Medical Education, I-st Department of Obstetrics and Gynecology, 01-813 Warsaw, Poland.
Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 00-001 Warsaw, Poland.
Int J Mol Sci. 2023 Jun 20;24(12):10401. doi: 10.3390/ijms241210401.
Perinatal hypoxia is a major cause of neurodevelopmental impairment and subsequent motor and cognitive dysfunctions; it is associated with fetal growth restriction and uteroplacental dysfunction during pregnancy. This review aims to present the current knowledge on brain development resulting from perinatal asphyxia, including the causes, symptoms, and means of predicting the degree of brain damage. Furthermore, this review discusses the specificity of brain development in the growth-restricted fetus and how it is replicated and studied in animal models. Finally, this review aims at identifying the least understood and missing molecular pathways of abnormal brain development, especially with respect to potential treatment intervention.
围产期缺氧是神经发育障碍以及随后的运动和认知功能障碍的主要原因；它与胎儿生长受限和妊娠期间的胎盘功能障碍有关。本综述旨在介绍围产期窒息引起的大脑发育的最新知识，包括原因、症状和预测脑损伤程度的方法。此外，本综述还讨论了生长受限胎儿大脑发育的特殊性，以及如何在动物模型中复制和研究这种特殊性。最后，本综述旨在确定异常大脑发育中最不为人知和缺失的分子途径，特别是在潜在的治疗干预方面。
