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了解并克服由N-6'-乙酰基转移酶引起的氨基糖苷类耐药性。

Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

作者信息

Vong Kenward, Auclair Karine

机构信息

Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec, Canada H3A 2K6.

出版信息

Medchemcomm. 2012 Apr 1;3(4):397-407. doi: 10.1039/C2MD00253A.

DOI:10.1039/C2MD00253A
PMID:28018574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5179255/
Abstract

Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however menacing to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6'--acetyltransferase (AAC(6')).

摘要

氨基糖苷类抗生素在抗生素中占据着特殊的地位，部分原因在于其广泛的抗菌谱。然而，细菌耐药性正威胁着使这些药物过时。大量工作致力于理解和克服氨基糖苷类抗生素耐药性。本综述将讨论氨基糖苷类修饰酶（AMEs），特别强调对理解和阻断由氨基糖苷6'-乙酰转移酶（AAC(6')）引起的耐药性所做的努力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/b4ae85c13a59/nihms6384f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/22170cacd7d4/nihms6384f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/b31561506e09/nihms6384f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/bef94a9f5309/nihms6384f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/580ea2b1baed/nihms6384f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/c40d19e46108/nihms6384f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/c1faae49054b/nihms6384f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/b4ae85c13a59/nihms6384f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/22170cacd7d4/nihms6384f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/b31561506e09/nihms6384f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/bef94a9f5309/nihms6384f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/580ea2b1baed/nihms6384f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/c40d19e46108/nihms6384f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/c1faae49054b/nihms6384f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bee/5179255/b4ae85c13a59/nihms6384f7.jpg

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