了解并克服由N-6'-乙酰基转移酶引起的氨基糖苷类耐药性。
Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.
作者信息
Vong Kenward, Auclair Karine
机构信息
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Québec, Canada H3A 2K6.
出版信息
Medchemcomm. 2012 Apr 1;3(4):397-407. doi: 10.1039/C2MD00253A.
Abstract
Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however menacing to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6'--acetyltransferase (AAC(6')).
摘要
氨基糖苷类抗生素在抗生素中占据着特殊的地位，部分原因在于其广泛的抗菌谱。然而，细菌耐药性正威胁着使这些药物过时。大量工作致力于理解和克服氨基糖苷类抗生素耐药性。本综述将讨论氨基糖苷类修饰酶（AMEs），特别强调对理解和阻断由氨基糖苷6'-乙酰转移酶（AAC(6')）引起的耐药性所做的努力。
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